Characterization of Liposarcoma Cell Lines for Preclinical and Biological Studies
Joint Authors
Daffinrud, Jeanette
Castro, Russell
Myklebost, Ola
Stratford, Eva W.
Skårn, Magne
Lauvrak, Silje
Munthe, Else
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Liposarcoma cell lines represent in vitro models for studying disease mechanisms at the cellular level and for preclinical evaluation of novel drugs.
To date there are a limited number of well-characterized models available.
In this study, nine immortal liposarcoma cell lines were evaluated for tumor-forming ability, stem cell- and differentiation potential, and metastatic potential, with the aim to generate a well-characterized liposarcoma cell line panel.
Detailed stem cell and differentiation marker analyses were also performed.
Five of the liposarcoma cell lines were tumorigenic, forming tumors in mice.
Interestingly, tumor-forming ability correlated with high proliferative capacity in vitro.
All the cell lines underwent adipocytic differentiation, but the degree varied.
Surprisingly, the expression of stem cell and differentiation markers did not correlate well with function.
Overall, the panel contains cell lines suited for in vivo analyses (LPS141, SA-4, T778, SW872, and LISA-2), for testing novel drugs targeting cancer stem cells (LPS141) and for studying tumor progression and metastasis (T449 and T778).
American Psychological Association (APA)
Stratford, Eva W.& Castro, Russell& Daffinrud, Jeanette& Skårn, Magne& Lauvrak, Silje& Munthe, Else…[et al.]. 2012. Characterization of Liposarcoma Cell Lines for Preclinical and Biological Studies. Sarcoma،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-449635
Modern Language Association (MLA)
Stratford, Eva W.…[et al.]. Characterization of Liposarcoma Cell Lines for Preclinical and Biological Studies. Sarcoma No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-449635
American Medical Association (AMA)
Stratford, Eva W.& Castro, Russell& Daffinrud, Jeanette& Skårn, Magne& Lauvrak, Silje& Munthe, Else…[et al.]. Characterization of Liposarcoma Cell Lines for Preclinical and Biological Studies. Sarcoma. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-449635
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449635