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The Role of Vitamin D Deficiency in the Incidence, Progression, and Complications of Type 1 Diabetes Mellitus
Joint Authors
Chakhtoura, Marlene
Azar, Sami T.
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The “nonclassic” role of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has been recently widely recognized.
In type 1 diabetes mellitus (T1D), it plays an immunomodulatory role through the vitamin D receptor (VDR) present on pancreatic and immune cells.
Specific VDR allelic variants have been associated with T1D in many countries.
Furthermore, vitamin D deficiency has been prevalent in T1D, and the seasonal and latitude variability in the incidence of T1D can be partly explained by the related variability in vitamin D level.
In fact, retrospective studies of vitamin D supplementation during pregnancy or infancy showed a lower incidence of T1D.
We will review the different mechanisms of the vitamin D protective effect against insulitis and present the available data on the role of vitamin D deficiency in the control, progression, and complications of T1D.
American Psychological Association (APA)
Chakhtoura, Marlene& Azar, Sami T.. 2013. The Role of Vitamin D Deficiency in the Incidence, Progression, and Complications of Type 1 Diabetes Mellitus. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-449636
Modern Language Association (MLA)
Chakhtoura, Marlene& Azar, Sami T.. The Role of Vitamin D Deficiency in the Incidence, Progression, and Complications of Type 1 Diabetes Mellitus. International Journal of Endocrinology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-449636
American Medical Association (AMA)
Chakhtoura, Marlene& Azar, Sami T.. The Role of Vitamin D Deficiency in the Incidence, Progression, and Complications of Type 1 Diabetes Mellitus. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-449636
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449636