The Interstitial Lymphatic Peritoneal Mesothelium Axis in Portal Hypertensive Ascites : When in Danger, Go Back to the Sea
Joint Authors
Arias, Jaime
Santamaría, L.
Prieto, Isabel
Aller, Maria-Angeles
Argudo, S.
de Miguel, M. P.
de Vicente, F.
Arias, Jorge L.
Source
International Journal of Inflammation
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-05
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Portal hypertension induces a splanchnic and systemic low-grade inflammatory response that could induce the expression of three phenotypes, named ischemia-reperfusion, leukocytic, and angiogenic phenotypes.During the splanchnic expression of these phenotypes, interstitial edema, increased lymph flow, and lymphangiogenesis are produced in the gastrointestinal tract.
Associated liver disease increases intestinal bacterial translocation, splanchnic lymph flow, and induces ascites and hepatorenal syndrome.
Extrahepatic cholestasis in the rat allows to study the worsening of the portal hypertensive syndrome when associated with chronic liver disease.
The splanchnic interstitium, the mesenteric lymphatics, and the peritoneal mesothelium seem to create an inflammatory pathway that could have a key pathophysiological relevance in the production of the portal hypertension syndrome complications.
The hypothetical comparison between the ascitic and the amniotic fluids allows for translational investigation.
From a phylogenetic point of view, the ancestral mechanisms for amniotic fluid production were essential for animal survival out of the aquatic environment.
However, their hypothetical appearance in the cirrhotic patient is considered pathological since ultimately they lead to ascites development.
But, the adult human being would take advantage of the potential beneficial effects of this “amniotic-like fluid” to manage the interstitial fluids without adverse effects when chronic liver disease aggravates.
American Psychological Association (APA)
Aller, Maria-Angeles& Prieto, Isabel& Argudo, S.& de Vicente, F.& Santamaría, L.& de Miguel, M. P.…[et al.]. 2010. The Interstitial Lymphatic Peritoneal Mesothelium Axis in Portal Hypertensive Ascites : When in Danger, Go Back to the Sea. International Journal of Inflammation،Vol. 2010, no. 2010, pp.1-18.
https://search.emarefa.net/detail/BIM-449638
Modern Language Association (MLA)
Aller, Maria-Angeles…[et al.]. The Interstitial Lymphatic Peritoneal Mesothelium Axis in Portal Hypertensive Ascites : When in Danger, Go Back to the Sea. International Journal of Inflammation No. 2010 (2010), pp.1-18.
https://search.emarefa.net/detail/BIM-449638
American Medical Association (AMA)
Aller, Maria-Angeles& Prieto, Isabel& Argudo, S.& de Vicente, F.& Santamaría, L.& de Miguel, M. P.…[et al.]. The Interstitial Lymphatic Peritoneal Mesothelium Axis in Portal Hypertensive Ascites : When in Danger, Go Back to the Sea. International Journal of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-18.
https://search.emarefa.net/detail/BIM-449638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449638