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Animal Models of Diabetic Neuropathy : Progress Since 1960s
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Diabetic or peripheral diabetic neuropathy (PDN) is one of the major complications among some other diabetic complications such as diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy.
The use of animal models in the research of diabetes and diabetic complications is very common when rats and mice are most commonly used for many reasons.
A numbers of animal models of diabetic and PDN have been developed in the last several decades such as streptozotocin-induced diabetic rat models, conventional or genetically modified or high-fat diet-fed C57BL/Ks (db/db) mice models, streptozotocin-induced C57BL6/J and ddY mice models, Chinese hamster neuropathic model, rhesus monkey PDN model, spontaneously diabetic WBN/Kob rat model, L-fucose-induced neropathic rat model, partial sciatic nerve ligated rat model, nonobese diabetic (NOD) mice model, spontaneously induced Ins2 Akita mice model, leptin-deficient (ob/ob) mice model, Otsuka Long-Evans Tokushima Fatty (OLETF) rat model, surgically-induced neuropathic model, and genetically modified Spontaneously Diabetic Torii (SDT) rat model, none of which are without limitations.
An animal model of diabetic or PDN should mimic the all major pathogeneses of human diabetic neuropathy.
Hence, this review comparatively evaluates the animal models of diabetic and PDN which are developed since 1960s with their advantages and disadvantages to help diabetic research groups in order to more accurately choose an appropriate model to meet their specific research objectives.
American Psychological Association (APA)
Islam, Md. Shahidul. 2013. Animal Models of Diabetic Neuropathy : Progress Since 1960s. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-449702
Modern Language Association (MLA)
Islam, Md. Shahidul. Animal Models of Diabetic Neuropathy : Progress Since 1960s. Journal of Diabetes Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-449702
American Medical Association (AMA)
Islam, Md. Shahidul. Animal Models of Diabetic Neuropathy : Progress Since 1960s. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-449702
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449702