Electroacupuncture-Induced Attenuation of Experimental Epilepsy : A Comparative Evaluation of Acupoints and Stimulation Parameters
Joint Authors
Xia, Ying
Shen, Xueyong
Kang, Xuezhi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The efficacy of electroacupuncture (EA) on epilepsy remains to be verified because of previous controversies that might be due to the complexity of the effects induced by different acupoints and stimulation approaches adopted.
Therefore, we investigated the effects of EA on epilepsy to determine the specific acupoints and optimal stimulation parameters in this work.
Experimental epilepsy was induced by injecting kainic acid to the lateral cerebral ventricle of adult male SD rats.
EA with a low-frequency (10 Hz/1 mA) or high-frequency (100 Hz/1 mA) current was applied to the epileptic model for 30 minutes starting at 0.5 hour after the injection.
Four pairs of acupoints were tested, that is, Shuigou (DU26) + Dazhui (DU14), Jinsuo (DU8) + Yaoqi (EXB9), Neiguan (PC6) + Quchi (LI11), and Fenglong (ST40) + Yongquan (KI1).
We found that (1) low- or high-frequency EA at different acupoints reduced epileptic seizures (P<0.05 versus the control) with an exception of low-frequency EA at Neiguan (PC6) and Quchi (LI11); (2) low-frequency EA induced a better effect at Fenglong (ST40) plus Yongquan (KI1) than that of the other acupoints (P<0.05); (3) there is no significant difference in the effects of high-frequency EA at these acupoints; and (4) the high-frequency EA elicited a greater effect than that of low-frequency EA in all groups (P<0.05), with an exception at Jinsuo (DU8) + Yaoqi (EXB9).
The EA-induced attenuation appeared 1–1.5 hours after EA with no appreciable effect in the first hour after EA in either the EEG or the behavioral tests.
We conclude that EA attenuation of epileptic seizures is dependent on the stimulation parameters and acupoints and that the delay in appearance of the EA effect could be a reflection of the time required by the EA signal to regulate neural function in the central nervous system.
American Psychological Association (APA)
Kang, Xuezhi& Shen, Xueyong& Xia, Ying. 2013. Electroacupuncture-Induced Attenuation of Experimental Epilepsy : A Comparative Evaluation of Acupoints and Stimulation Parameters. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-449718
Modern Language Association (MLA)
Kang, Xuezhi…[et al.]. Electroacupuncture-Induced Attenuation of Experimental Epilepsy : A Comparative Evaluation of Acupoints and Stimulation Parameters. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-449718
American Medical Association (AMA)
Kang, Xuezhi& Shen, Xueyong& Xia, Ying. Electroacupuncture-Induced Attenuation of Experimental Epilepsy : A Comparative Evaluation of Acupoints and Stimulation Parameters. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-449718
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449718