Increased Upper and Lower Tract Urothelial Carcinoma in Patients with End-Stage Renal Disease : A Nationwide Cohort Study in Taiwan during 1997–2008
Joint Authors
Wang, Jung-Der
Chen, Pau-Chung
Pu, Yeong-Shiau
Hwang, Jing-Shiang
Wang, Shuo-Meng
Lai, Ming-Nan
Lai, Ming-Kuen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Urothelial cancer (UC) is the leading cancer of patients with end-stage renal disease (ESRD) in Taiwan.
The aims of this study were to explore the time trends of UC incidences and propose possible etiologic factors.
Methods.
Abstracting from the National Health Insurance Research Database (NHIRD), there were 90,477 newly diagnosed cases of ESRD between 1997 and 2008 covering the patients aged 40–85.
Among them, 2,708 had developed UC after diagnosis of ESRD.
The CIR40–85 (cumulative incidence rate) of upper tract UC (UTUC) and lower tract UC (LTUC) were calculated for ESRD patients and general population, as well as SIR40–85 (standardized incidence ratio) for comparison.
Results.
Female ESRD patients were found to have 9–18 times of elevated risks of UC, while those of males were increased up to 4–14 times.
The time trends of CIR40–84 and SIR40–84 of UTUC in females appear to decline after calendar year 2000.
These trends may be related to AA associated herbal products after 1998.
Conclusions.
Patients with ESRD are at increased risks for both LTUC and UTUC in Taiwan.
We hypothesize that the time trends associate with the consumption of aristolochic acid in Chinese herbal products (female predominant).
American Psychological Association (APA)
Wang, Shuo-Meng& Lai, Ming-Nan& Chen, Pau-Chung& Pu, Yeong-Shiau& Lai, Ming-Kuen& Hwang, Jing-Shiang…[et al.]. 2014. Increased Upper and Lower Tract Urothelial Carcinoma in Patients with End-Stage Renal Disease : A Nationwide Cohort Study in Taiwan during 1997–2008. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-449737
Modern Language Association (MLA)
Wang, Shuo-Meng…[et al.]. Increased Upper and Lower Tract Urothelial Carcinoma in Patients with End-Stage Renal Disease : A Nationwide Cohort Study in Taiwan during 1997–2008. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-449737
American Medical Association (AMA)
Wang, Shuo-Meng& Lai, Ming-Nan& Chen, Pau-Chung& Pu, Yeong-Shiau& Lai, Ming-Kuen& Hwang, Jing-Shiang…[et al.]. Increased Upper and Lower Tract Urothelial Carcinoma in Patients with End-Stage Renal Disease : A Nationwide Cohort Study in Taiwan during 1997–2008. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-449737
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449737