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New and Old Mechanisms Associated with Hypertension in the Elderly
Joint Authors
López-Farré, Antonio J.
Zamorano-León, Jose J.
Mateos-Cáceres, Petra J.
Macaya, Carlos
Rodríguez-Sierra, Pablo
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hypertension is a widely prevalent and important risk factor for cardiovascular diseases that increase with aging.
The hallmark of hypertension in the elderly is increased vascular dysfunction.
However, the molecular mechanisms by which increased blood pressure leads to vascular injury and impaired endothelial function are not well defined.
In the present paper, we will analyze several mechanisms described in the scientific literature involved in hypertension in the elderly as endothelial dysfunction, increased oxygen delivery to tissues, inflammation, cellular apoptosis, and increased concentration of active metabolites.
Also, we will focus on new molecular mechanisms involved in hypertension such as telomeres shortening, progenitor cells, circulating microparticles, and epigenetic factors that have appeared as possible causes of hypertension in the elderly.
These molecular mechanisms may elucidate different origin for hypertension in the elderly and provide us with new targets for hypertension treatment.
American Psychological Association (APA)
Mateos-Cáceres, Petra J.& Zamorano-León, Jose J.& Rodríguez-Sierra, Pablo& Macaya, Carlos& López-Farré, Antonio J.. 2011. New and Old Mechanisms Associated with Hypertension in the Elderly. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-449751
Modern Language Association (MLA)
Mateos-Cáceres, Petra J.…[et al.]. New and Old Mechanisms Associated with Hypertension in the Elderly. International Journal of Hypertension No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-449751
American Medical Association (AMA)
Mateos-Cáceres, Petra J.& Zamorano-León, Jose J.& Rodríguez-Sierra, Pablo& Macaya, Carlos& López-Farré, Antonio J.. New and Old Mechanisms Associated with Hypertension in the Elderly. International Journal of Hypertension. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-449751
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449751