Gaucher Disease and Cancer : Concept and Controversy
Joint Authors
Campbell, Tessa N.
Choy, Francis Y. M.
Source
International Journal of Cell Biology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Gaucher disease is an inherited disorder caused by a deficiency in the lysosomal hydrolase glucocerebrosidase.
There is a wide spectrum of clinical presentations, with the most common features being hepatosplenomegaly, skeletal disease, and cytopenia.
Gaucher disease has been classified into three broad phenotypes based upon the presence or absence of neurological involvement: Type 1 (nonneuronopathic), Type 2 (acute neuronopathic), and Type 3 (subacute neuronopathic).
The two main treatment options include enzyme replacement therapy and substrate reduction therapy.
Recently, discussion has escalated around the association of Gaucher disease and cancer, with conflicting reports as to whether Gaucher patients have an increased risk of malignancy.
In this review, we present both the concept and controversy surrounding the association of Gaucher disease with cancer.
American Psychological Association (APA)
Choy, Francis Y. M.& Campbell, Tessa N.. 2011. Gaucher Disease and Cancer : Concept and Controversy. International Journal of Cell Biology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-449785
Modern Language Association (MLA)
Choy, Francis Y. M.& Campbell, Tessa N.. Gaucher Disease and Cancer : Concept and Controversy. International Journal of Cell Biology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-449785
American Medical Association (AMA)
Choy, Francis Y. M.& Campbell, Tessa N.. Gaucher Disease and Cancer : Concept and Controversy. International Journal of Cell Biology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-449785
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449785