M. paratuberculosis Heat Shock Protein 65 and Human Diseases : Bridging Infection and Autoimmunity
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Mycobacterium avium subspecies paratuberculosis (MAP) is the known infectious cause of Johne’s disease, an enteric inflammatory disease mostly studied in ruminant animals.
MAP has also been implicated in the very similar Crohn’s disease of humans as well as sarcoidosis.
Recently, MAP has been associated with juvenile sarcoidosis (Blau syndrome), autoimmune diabetes, autoimmune thyroiditis, and multiple sclerosis.
While it is intuitive to implicate MAP in granulomatous diseases where the microbe participates in the granuloma, it is more difficult to assign a role for MAP in diseases where autoantibodies are a primary feature.
MAP may trigger autoimmune antibodies via its heat shock proteins.
Mycobacterial heat shock protein 65 (HSP65) is an immunodominant protein that shares sequential and conformational elements with several human host proteins.
This molecular mimicry is the proposed etiopathology by which MAP stimulates autoantibodies associated with autoimmune (type 1) diabetes, autoimmune (Hashimoto’s) thyroiditis, and multiple sclerosis.
This paper proposes that MAP is a source of mycobacterial HSP65 and acts as a trigger of autoimmune disease.
American Psychological Association (APA)
Dow, Coad Thomas. 2012. M. paratuberculosis Heat Shock Protein 65 and Human Diseases : Bridging Infection and Autoimmunity. Autoimmune Diseases،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-449826
Modern Language Association (MLA)
Dow, Coad Thomas. M. paratuberculosis Heat Shock Protein 65 and Human Diseases : Bridging Infection and Autoimmunity. Autoimmune Diseases No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-449826
American Medical Association (AMA)
Dow, Coad Thomas. M. paratuberculosis Heat Shock Protein 65 and Human Diseases : Bridging Infection and Autoimmunity. Autoimmune Diseases. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-449826
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449826