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Morphine and Clonidine Synergize to Ameliorate Low Back Pain in Mice
Joint Authors
Millecamps, Magali
Stone, Laura S.
Tajerian, Maral
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Chronic low back pain (LBP) is a debilitating condition associated with signs of axial and radiating pain.
In humans with chronic LBP, opioids are often prescribed with varying outcomes and a multitude of side effects.
Combination therapies, in which multiple pharmacological agents synergize to ameliorate pain without similar potentiation of adverse reactions, may be useful in improving therapeutic outcome in these patients.
The SPARC-null mouse model of low back pain due to disc degeneration was used to assess the effects of opioid (morphine) and α2-adrenergic agonist (clonidine) coadministration on measures of axial and radiating pain.
The results indicate that systemic morphine and clonidine, coadministered at a fixed dose of 100 : 1 (morphine : clonidine), show a synergistic interaction in reversing signs of axial LBP, in addition to improving the therapeutic window for radiating LBP.
Furthermore, these improvements were observed in the absence of synergy in assays of motor function which are indicative of side effects such as sedation and motor incoordination.
These data show that the addition of low-dose systemic clonidine improves therapeutic outcome in measures of both axial and radiating pain.
Combination therapy could be of enormous benefit to patients suffering from chronic LBP.
American Psychological Association (APA)
Tajerian, Maral& Millecamps, Magali& Stone, Laura S.. 2012. Morphine and Clonidine Synergize to Ameliorate Low Back Pain in Mice. Pain Research and Treatment،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-449830
Modern Language Association (MLA)
Tajerian, Maral…[et al.]. Morphine and Clonidine Synergize to Ameliorate Low Back Pain in Mice. Pain Research and Treatment No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-449830
American Medical Association (AMA)
Tajerian, Maral& Millecamps, Magali& Stone, Laura S.. Morphine and Clonidine Synergize to Ameliorate Low Back Pain in Mice. Pain Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-449830
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449830