Gender Effects on Plasma and Brain Copper
Joint Authors
Carter, Raina
Quinn, Joseph F.
Kaye, Jeffrey A.
Ralle, Martina
Lind, Babett
Harris, Christopher
Anekonda, Thimmappa
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-19
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The effect of gender on systemic and brain levels of copper is relatively understudied.
We examined gender effects in mice and human subjects.
We observed a trend to higher serum copper levels in female compared to male LaFerla “triple transgenic” (1399±233 versus 804±436 ng/mL, P=0.06) mice, and significantly higher brain copper levels in female- versus male wild-type mice (5.2±0.2 versus 4.18±0.3 ng/mg wet wt, P=0.03).
Plasma copper was significantly correlated with brain copper in mice (R2 = 0.218; P=0.038).
Among human subjects with AD, both plasma copper (1284±118 versus 853±81 ng/mL, P=0.005) and cerebrospinal fluid copper (12.8±1 versus 10.4±0.7 ng/mL, P=0.01) were elevated in women compared to men.
Among healthy control subjects, plasma copper (1008±51 versus 836±41 ng/mL; P=0.01) was higher in women than in men, but there was no difference in cerebrospinal fluid copper.
We conclude that gender differences in copper status may influence copper-mediated pathological events in the brain.
American Psychological Association (APA)
Quinn, Joseph F.& Harris, Christopher& Kaye, Jeffrey A.& Lind, Babett& Carter, Raina& Anekonda, Thimmappa…[et al.]. 2011. Gender Effects on Plasma and Brain Copper. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-449833
Modern Language Association (MLA)
Quinn, Joseph F.…[et al.]. Gender Effects on Plasma and Brain Copper. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-449833
American Medical Association (AMA)
Quinn, Joseph F.& Harris, Christopher& Kaye, Jeffrey A.& Lind, Babett& Carter, Raina& Anekonda, Thimmappa…[et al.]. Gender Effects on Plasma and Brain Copper. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-449833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449833