Plantago ovata F. Mucilage-Alginate Mucoadhesive Beads for Controlled Release of Glibenclamide : Development, Optimization, and In Vitro-In Vivo Evaluation
Joint Authors
Nayak, Amit Kumar
Santra, Kousik
Pal, Dilipkumar
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Pharmacy, Health & Medical Sciences
Economics & Business Administration
Pharmacology
Abstract EN
The current study deals with the development and optimization of ispaghula (Plantago ovata F.) husk mucilage- (IHM-) alginate mucoadhesive beads containing glibenclamide by ionotropic gelation technique.
The effects of sodium alginate (SA) to IHM and cross-linker (CaCl2) concentration on the drug encapsulation efficiency (DEE, %), as well as cumulative drug release after 10 hours (R10 h, %), were optimized using 32 factorial design based on response surface methodology.
The observed responses were coincided well with the predicted values by the experimental design.
The optimized mucoadhesive beads exhibited 94.43±4.80% w/w of DEE and good mucoadhesivity with the biological membrane in wash-off test and sustained drug release profile over 10 hours.
The beads were also characterized by SEM and FTIR analyses.
The in vitro drug release from these beads was followed by controlled release (zero-order) pattern with super case-II transport mechanism.
The optimized glibenclamide-loaded IHM-alginate mucoadhesive beads showed significant antidiabetic effect in alloxan-induced diabetic rats over prolonged period after oral administration.
American Psychological Association (APA)
Nayak, Amit Kumar& Pal, Dilipkumar& Santra, Kousik. 2013. Plantago ovata F. Mucilage-Alginate Mucoadhesive Beads for Controlled Release of Glibenclamide : Development, Optimization, and In Vitro-In Vivo Evaluation. Journal of Pharmaceutics،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-449852
Modern Language Association (MLA)
Nayak, Amit Kumar…[et al.]. Plantago ovata F. Mucilage-Alginate Mucoadhesive Beads for Controlled Release of Glibenclamide : Development, Optimization, and In Vitro-In Vivo Evaluation. Journal of Pharmaceutics No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-449852
American Medical Association (AMA)
Nayak, Amit Kumar& Pal, Dilipkumar& Santra, Kousik. Plantago ovata F. Mucilage-Alginate Mucoadhesive Beads for Controlled Release of Glibenclamide : Development, Optimization, and In Vitro-In Vivo Evaluation. Journal of Pharmaceutics. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-449852
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449852