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The Gut Microbiota and Irritable Bowel Syndrome : Friend or Foe?
Joint Authors
Ghoshal, Ujjala
Shukla, Ratnakar
Ng, Siew C.
Gwee, Kok-Ann
Quigley, Eamonn M. M.
Ghoshal, Uday C.
Source
International Journal of Inflammation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Progress in the understanding of the pathophysiology of irritable bowel syndrome (IBS), once thought to be a purely psychosomatic disease, has advanced considerably and low-grade inflammation and changes in the gut microbiota now feature as potentially important.
The human gut harbours a huge microbial ecosystem, which is equipped to perform a variety of functions such as digestion of food, metabolism of drugs, detoxification of toxic compounds, production of essential vitamins, prevention of attachment of pathogenic bacteria to the gut wall, and maintenance of homeostasis in the gastrointestinal tract.
A subset of patients with IBS may have a quantitative increase in bacteria in the small bowel (small intestinal bacterial overgrowth).
Qualitative changes in gut microbiota have also been associated with IBS.
Targeting the gut microbiota using probiotics and antibiotics has emerged as a potentially effective approach to the treatment of this, hitherto enigmatic, functional bowel disorder.
The gut microbiota in health, quantitative and qualitative microbiota changes, and therapeutic manipulations targeting the microbiota in patients with IBS are reviewed in this paper.
American Psychological Association (APA)
Ghoshal, Uday C.& Shukla, Ratnakar& Ghoshal, Ujjala& Gwee, Kok-Ann& Ng, Siew C.& Quigley, Eamonn M. M.. 2012. The Gut Microbiota and Irritable Bowel Syndrome : Friend or Foe?. International Journal of Inflammation،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-449854
Modern Language Association (MLA)
Ghoshal, Uday C.…[et al.]. The Gut Microbiota and Irritable Bowel Syndrome : Friend or Foe?. International Journal of Inflammation No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-449854
American Medical Association (AMA)
Ghoshal, Uday C.& Shukla, Ratnakar& Ghoshal, Ujjala& Gwee, Kok-Ann& Ng, Siew C.& Quigley, Eamonn M. M.. The Gut Microbiota and Irritable Bowel Syndrome : Friend or Foe?. International Journal of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-449854
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449854