![](/images/graphics-bg.png)
Gut Microbial Translocation in Critically Ill Children and Effects of Supplementation with Pre- and Pro Biotics
Joint Authors
Cerasaro, Carla
Ceccarelli, Giancarlo
Moretti, Corrado
Midulla, Fabio
d'Ettorre, Gabriella
Caresta, Elena
Papoff, Paola
Source
International Journal of Microbiology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
Bacterial translocation as a direct cause of sepsis is an attractive hypothesis that presupposes that in specific situations bacteria cross the intestinal barrier, enter the systemic circulation, and cause a systemic inflammatory response syndrome.
Critically ill children are at increased risk for bacterial translocation, particularly in the early postnatal age.
Predisposing factors include intestinal obstruction, obstructive jaundice, intra-abdominal hypertension, intestinal ischemia/reperfusion injury and secondary ileus, and immaturity of the intestinal barrier per se.
Despite good evidence from experimental studies to support the theory of bacterial translocation as a cause of sepsis, there is little evidence in human studies to confirm that translocation is directly correlated to bloodstream infections in critically ill children.
This paper provides an overview of the gut microflora and its significance, a focus on the mechanisms employed by bacteria to gain access to the systemic circulation, and how critical illness creates a hostile environment in the gut and alters the microflora favoring the growth of pathogens that promote bacterial translocation.
It also covers treatment with pre- and pro biotics during critical illness to restore the balance of microbial communities in a beneficial way with positive effects on intestinal permeability and bacterial translocation.
American Psychological Association (APA)
Papoff, Paola& Ceccarelli, Giancarlo& d'Ettorre, Gabriella& Cerasaro, Carla& Caresta, Elena& Midulla, Fabio…[et al.]. 2012. Gut Microbial Translocation in Critically Ill Children and Effects of Supplementation with Pre- and Pro Biotics. International Journal of Microbiology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-449871
Modern Language Association (MLA)
Papoff, Paola…[et al.]. Gut Microbial Translocation in Critically Ill Children and Effects of Supplementation with Pre- and Pro Biotics. International Journal of Microbiology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-449871
American Medical Association (AMA)
Papoff, Paola& Ceccarelli, Giancarlo& d'Ettorre, Gabriella& Cerasaro, Carla& Caresta, Elena& Midulla, Fabio…[et al.]. Gut Microbial Translocation in Critically Ill Children and Effects of Supplementation with Pre- and Pro Biotics. International Journal of Microbiology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-449871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449871