Inhibition of Candida albicans by Fluvastatin Is Dependent on pH
Joint Authors
Boyer, Michael P.
Dzogbeta, Seli
Schmidt, Martin
Source
Research Letters in Biochemistry
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-05
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The cholesterol-lowering drug fluvastatin (FS) has an inhibitory effect on the growth of the pathogenic yeast Candida albicans that is dependent on the pH of the medium.
At the low pH value of the vagina, FS is growth inhibitory at low and at high concentrations, while at intermediate concentrations (1–10 mM), it has no inhibitory effect.
Examination of the effect of the common antifungal drug fluconazole in combination with FS demonstrates drug interactions in the low concentration range.
Determination of intracellular stress and the activity of the FS target enzyme HMG-CoA reductase confirm our hypothesis that in the intermediate dose range adjustments to the sterol biosynthesis pathway can compensate for the action of FS.
We conclude that the pH dependent uptake of FS across yeast membranes might make FS combination therapy an attractive possibility for treatment of vaginal C.
albicans infections.
American Psychological Association (APA)
Schmidt, Martin& Dzogbeta, Seli& Boyer, Michael P.. 2009. Inhibition of Candida albicans by Fluvastatin Is Dependent on pH. Research Letters in Biochemistry،Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-449875
Modern Language Association (MLA)
Schmidt, Martin…[et al.]. Inhibition of Candida albicans by Fluvastatin Is Dependent on pH. Research Letters in Biochemistry No. 2009 (2009), pp.1-4.
https://search.emarefa.net/detail/BIM-449875
American Medical Association (AMA)
Schmidt, Martin& Dzogbeta, Seli& Boyer, Michael P.. Inhibition of Candida albicans by Fluvastatin Is Dependent on pH. Research Letters in Biochemistry. 2009. Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-449875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449875