Detection of Soluble Amyloid-β Oligomers and Insoluble High-Molecular-Weight Particles in CSF : Development of Methods with Potential for Diagnosis and Therapy Monitoring of Alzheimer's Disease
Author
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The diagnosis of probable Alzheimer's disease (AD) can be established premortem based on clinical criteria like neuropsychological tests.
Post mortem, specific neuropathological changes like amyloid plaques define AD.
However, the standard criteria based on medical history and mental status examinations do not take into account the long preclinical features of the disease, and a biomarker for improved diagnosis of AD is urgently needed.
In a large number of studies, amyloid-β (Aβ) monomer concentrations in CSF of AD patients are consistently and significantly reduced when compared to healthy controls.
Therefore, monomeric Aβ in CSF was suggested to be a helpful biomarker for the diagnosis of preclinical AD.
However, not the monomeric form, but Aβ oligomers have been shown to be the toxic species in AD pathology, and their quantification and characterization could facilitate AD diagnosis and therapy monitoring.
Here, we review the current status of assay development to reliably and routinely detect Aβ oligomers and high-molecular-weight particles in CSF.
American Psychological Association (APA)
Funke, Susanne Aileen. 2011. Detection of Soluble Amyloid-β Oligomers and Insoluble High-Molecular-Weight Particles in CSF : Development of Methods with Potential for Diagnosis and Therapy Monitoring of Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-449896
Modern Language Association (MLA)
Funke, Susanne Aileen. Detection of Soluble Amyloid-β Oligomers and Insoluble High-Molecular-Weight Particles in CSF : Development of Methods with Potential for Diagnosis and Therapy Monitoring of Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-449896
American Medical Association (AMA)
Funke, Susanne Aileen. Detection of Soluble Amyloid-β Oligomers and Insoluble High-Molecular-Weight Particles in CSF : Development of Methods with Potential for Diagnosis and Therapy Monitoring of Alzheimer's Disease. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-449896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449896