GCK Gene-Body Hypomethylation Is Associated with the Risk of Coronary Heart Disease
Joint Authors
Zhou, Qingyun
Liu, Haibo
Liao, Qi
Jiang, Danjie
Shao, Guofeng
Xu, Limin
Wang, Lingyan
Zhang, Lina
Le, Yanping
Li, Ni
Shi, Xinbao
Huang, Yi
Liu, Panpan
Wang, Zhaoyang
Duan, Shiwei
Xu, Leiting
Zheng, Dawei
Sun, Lebo
Ye, Meng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
Glucokinase encoded by GCK is a key enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate.
Variants of GCK gene were shown to be associated with type 2 diabetes (T2D) and coronary heart disease (CHD).
The goal of this study was to investigate the contribution of GCK gene-body methylation to the risk of CHD.
Design and Methods.
36 patients (18 males and 18 females) and 36 age- and sex-matched controls were collected for the current methylation research.
DNA methylation level of the CpG island (CGI) region on the GCK gene-body was measured through the sodium bisulfite DNA conversion and pyrosequencing technology.
Results.
Our results indicated that CHD cases have a much lower methylation level (49.77 ± 6.43%) compared with controls (54.47 ± 7.65%, P=0.018).
In addition, GCK gene-body methylation was found to be positively associated with aging in controls (r=0.443, P=0.010).
Conclusions.
Our study indicated that the hypomethylation of GCK gene-body was significantly associated with the risk of CHD.
Aging correlates with an elevation of GCK methylation in healthy controls.
American Psychological Association (APA)
Xu, Limin& Zheng, Dawei& Wang, Lingyan& Jiang, Danjie& Liu, Haibo& Xu, Leiting…[et al.]. 2014. GCK Gene-Body Hypomethylation Is Associated with the Risk of Coronary Heart Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-449902
Modern Language Association (MLA)
Xu, Limin…[et al.]. GCK Gene-Body Hypomethylation Is Associated with the Risk of Coronary Heart Disease. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-449902
American Medical Association (AMA)
Xu, Limin& Zheng, Dawei& Wang, Lingyan& Jiang, Danjie& Liu, Haibo& Xu, Leiting…[et al.]. GCK Gene-Body Hypomethylation Is Associated with the Risk of Coronary Heart Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-449902
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449902