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Comparison of Insulin Lispro Protamine Suspension with NPH Insulin in Pregnant Women with Type 2 and Gestational Diabetes Mellitus : Maternal and Perinatal Outcomes
Joint Authors
Abbruzzese, Santina
Leotta, Sergio
Bongiovanni, Marzia
Colatrella, Antonietta
Napoli, Angela
Visalli, Natalia
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Insulin therapy is still the gold standard in diabetic pregnancy.
Insulin lispro protamine suspension is an available basal insulin analogue.
Aim.
To study pregnancy outcomes of women with type 2 and gestational diabetes mellitus when insulin lispro protamine suspension or human NPH insulin was added to medical nutrition therapy and/or short-acting insulin.
Methods.
In this retrospective study, for maternal outcome we recorded time and mode of delivery, hypertension, glycaemic control (fasting blood glucose and HbA1c), hypoglycemias, weight increase, and insulin need.
For neonatal outcome birth weight and weight class, congenital malformations was recorded and main neonatal complications.
Two-tail Student's t-test and chi-square test were performed when applicable; significant P<0.05.
Results.
Eighty-nine pregnant women (25 with type 2 diabetes and 64 with gestational diabetes mellitus; 53 under insulin lispro protamine suspension and 36 under human NPH insulin) were recruited.
Maternal and neonatal outcomes were quite similar between the two therapeutic approaches; however, insulin need was higher in NPH.
At the end of pregnancy, eight women with gestational diabetes continued to use only basal insulin analogue.
Conclusions.
Pregnancy outcome in type 2 and gestational diabetes mellitus with insulin lispro protamine suspension was similar to that with NPH insulin, except for a lower insulin requirement.
American Psychological Association (APA)
Colatrella, Antonietta& Visalli, Natalia& Abbruzzese, Santina& Leotta, Sergio& Bongiovanni, Marzia& Napoli, Angela. 2013. Comparison of Insulin Lispro Protamine Suspension with NPH Insulin in Pregnant Women with Type 2 and Gestational Diabetes Mellitus : Maternal and Perinatal Outcomes. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-449925
Modern Language Association (MLA)
Colatrella, Antonietta…[et al.]. Comparison of Insulin Lispro Protamine Suspension with NPH Insulin in Pregnant Women with Type 2 and Gestational Diabetes Mellitus : Maternal and Perinatal Outcomes. International Journal of Endocrinology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-449925
American Medical Association (AMA)
Colatrella, Antonietta& Visalli, Natalia& Abbruzzese, Santina& Leotta, Sergio& Bongiovanni, Marzia& Napoli, Angela. Comparison of Insulin Lispro Protamine Suspension with NPH Insulin in Pregnant Women with Type 2 and Gestational Diabetes Mellitus : Maternal and Perinatal Outcomes. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-449925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449925