LOX-1, OxLDL, and Atherosclerosis
Joint Authors
Catapano, Alberico Luigi
Norata, Giuseppe Danilo
Pirillo, Angela
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Oxidized low-density lipoprotein (OxLDL) contributes to the atherosclerotic plaque formation and progression by several mechanisms, including the induction of endothelial cell activation and dysfunction, macrophage foam cell formation, and smooth muscle cell migration and proliferation.
Vascular wall cells express on their surface several scavenger receptors that mediate the cellular effects of OxLDL.
The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is the main OxLDL receptor of endothelial cells, and it is expressed also in macrophages and smooth muscle cells.
LOX-1 is almost undetectable under physiological conditions, but it is upregulated following the exposure to several proinflammatory and proatherogenic stimuli and can be detected in animal and human atherosclerotic lesions.
The key contribution of LOX-1 to the atherogenic process has been confirmed in animal models; LOX-1 knockout mice exhibit reduced intima thickness and inflammation and increased expression of protective factors; on the contrary, LOX-1 overexpressing mice present an accelerated atherosclerotic lesion formation which is associated with increased inflammation.
In humans, LOX-1 gene polymorphisms were associated with increased susceptibility to myocardial infarction.
Inhibition of the LOX-1 receptor with chemicals or antisense nucleotides is currently being investigated and represents an emerging approach for controlling OxLDL-LOX-1 mediated proatherogenic effects.
American Psychological Association (APA)
Pirillo, Angela& Norata, Giuseppe Danilo& Catapano, Alberico Luigi. 2013. LOX-1, OxLDL, and Atherosclerosis. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-449992
Modern Language Association (MLA)
Pirillo, Angela…[et al.]. LOX-1, OxLDL, and Atherosclerosis. Mediators of Inflammation No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-449992
American Medical Association (AMA)
Pirillo, Angela& Norata, Giuseppe Danilo& Catapano, Alberico Luigi. LOX-1, OxLDL, and Atherosclerosis. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-449992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449992