LOX-1, OxLDL, and Atherosclerosis

Joint Authors

Catapano, Alberico Luigi
Norata, Giuseppe Danilo
Pirillo, Angela

Source

Mediators of Inflammation

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-07-10

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Diseases

Abstract EN

Oxidized low-density lipoprotein (OxLDL) contributes to the atherosclerotic plaque formation and progression by several mechanisms, including the induction of endothelial cell activation and dysfunction, macrophage foam cell formation, and smooth muscle cell migration and proliferation.

Vascular wall cells express on their surface several scavenger receptors that mediate the cellular effects of OxLDL.

The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is the main OxLDL receptor of endothelial cells, and it is expressed also in macrophages and smooth muscle cells.

LOX-1 is almost undetectable under physiological conditions, but it is upregulated following the exposure to several proinflammatory and proatherogenic stimuli and can be detected in animal and human atherosclerotic lesions.

The key contribution of LOX-1 to the atherogenic process has been confirmed in animal models; LOX-1 knockout mice exhibit reduced intima thickness and inflammation and increased expression of protective factors; on the contrary, LOX-1 overexpressing mice present an accelerated atherosclerotic lesion formation which is associated with increased inflammation.

In humans, LOX-1 gene polymorphisms were associated with increased susceptibility to myocardial infarction.

Inhibition of the LOX-1 receptor with chemicals or antisense nucleotides is currently being investigated and represents an emerging approach for controlling OxLDL-LOX-1 mediated proatherogenic effects.

American Psychological Association (APA)

Pirillo, Angela& Norata, Giuseppe Danilo& Catapano, Alberico Luigi. 2013. LOX-1, OxLDL, and Atherosclerosis. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-449992

Modern Language Association (MLA)

Pirillo, Angela…[et al.]. LOX-1, OxLDL, and Atherosclerosis. Mediators of Inflammation No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-449992

American Medical Association (AMA)

Pirillo, Angela& Norata, Giuseppe Danilo& Catapano, Alberico Luigi. LOX-1, OxLDL, and Atherosclerosis. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-449992

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-449992