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The Molecular Epidemiology of Chronic Aflatoxin Driven Impaired Child Growth
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-19
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Diseases
Abstract EN
Aflatoxins are toxic secondary fungal metabolites that contaminate dietary staples in tropical regions; chronic high levels of exposure are common for many of the poorest populations.
Observations in animals indicate that growth and/or food utilization are adversely affected by aflatoxins.
This review highlights the development of validated exposure biomarkers and their use here to assess the role of aflatoxins in early life growth retardation.
Aflatoxin exposure occurs in utero and continues in early infancy as weaning foods are introduced.
Using aflatoxin-albumin exposure biomarkers, five major studies clearly demonstrate strong dose response relationships between exposure in utero and/or early infancy and growth retardation, identified by reduced birth weight and/or low HAZ and WAZ scores.
The epidemiological studies include cross-sectional and longitudinal surveys, though aflatoxin reduction intervention studies are now required to further support these data and guide sustainable options to reduce the burden of exposure.
The use of aflatoxin exposure biomarkers was essential in understanding the observational data reviewed and will likely be a critical monitor of the effectiveness of interventions to restrict aflatoxin exposure.
Given that an estimated 4.5 billion individuals live in regions at risk of dietary contamination the public health concern cannot be over stated.
American Psychological Association (APA)
Turner, Paul Craig. 2013. The Molecular Epidemiology of Chronic Aflatoxin Driven Impaired Child Growth. Scientifica،Vol. 2013, no. 2013, pp.1-21.
https://search.emarefa.net/detail/BIM-450003
Modern Language Association (MLA)
Turner, Paul Craig. The Molecular Epidemiology of Chronic Aflatoxin Driven Impaired Child Growth. Scientifica No. 2013 (2013), pp.1-21.
https://search.emarefa.net/detail/BIM-450003
American Medical Association (AMA)
Turner, Paul Craig. The Molecular Epidemiology of Chronic Aflatoxin Driven Impaired Child Growth. Scientifica. 2013. Vol. 2013, no. 2013, pp.1-21.
https://search.emarefa.net/detail/BIM-450003
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450003