Isoflavones and PPAR Signaling : A Critical Target in Cardiovascular, Metastatic, and Metabolic Disease
Joint Authors
Patel, Rakesh P.
Barnes, Stephen
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Isoflavone intake through foods and dietary supplements has both health advocates and critics.
The latter come from a concern about the estrogenic effects of isoflavones in certain species.
However, careful removal of isoflavones and other estrogens from the diet of rodents leads to the metabolic syndrome.
These results suggest that isoflavones have other mechanisms of action, potentially those involving regulation of fatty acid metabolism via the nuclear receptors PPARα and PPARγ.
The goal of this paper was to examine the evidence for isoflavone/PPAR signaling and to identify diseases in which such signaling would have an important impact.
It is therefore of note that investigators using a chemical structure approach to discover PPAR ligands identified isoflavones as the best structures in the library of compounds that they tested.
Future studies will involve careful identification of the underlying mechanisms whereby isoflavones have their action via PPAR signaling.
American Psychological Association (APA)
Patel, Rakesh P.& Barnes, Stephen. 2011. Isoflavones and PPAR Signaling : A Critical Target in Cardiovascular, Metastatic, and Metabolic Disease. PPAR Research،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-450043
Modern Language Association (MLA)
Patel, Rakesh P.& Barnes, Stephen. Isoflavones and PPAR Signaling : A Critical Target in Cardiovascular, Metastatic, and Metabolic Disease. PPAR Research No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-450043
American Medical Association (AMA)
Patel, Rakesh P.& Barnes, Stephen. Isoflavones and PPAR Signaling : A Critical Target in Cardiovascular, Metastatic, and Metabolic Disease. PPAR Research. 2011. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-450043
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450043