Functional Avidity : A Measure to Predict the Efficacy of Effector T Cells?
Joint Authors
Harari, Alexandre
Viganò, Selena
Zehn, Dietmar
Pantaleo, Giuseppe
Perreau, Matthieu
Utzschneider, Daniel T.
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-20
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The functional avidity is determined by exposing T-cell populations in vitro to different amounts of cognate antigen.
T-cells with high functional avidity respond to low antigen doses.
This in vitro measure is thought to correlate well with the in vivo effector capacity of T-cells.
We here present the multifaceted factors determining and influencing the functional avidity of T-cells.
We outline how changes in the functional avidity can occur over the course of an infection.
This process, known as avidity maturation, can occur despite the fact that T-cells express a fixed TCR.
Furthermore, examples are provided illustrating the importance of generating T-cell populations that exhibit a high functional avidity when responding to an infection or tumors.
Furthermore, we discuss whether criteria based on which we evaluate an effective T-cell response to acute infections can also be applied to chronic infections such as HIV.
Finally, we also focus on observations that high-avidity T-cells show higher signs of exhaustion and facilitate the emergence of virus escape variants.
The review summarizes our current understanding of how this may occur as well as how T-cells of different functional avidity contribute to antiviral and anti-tumor immunity.
Enhancing our knowledge in this field is relevant for tumor immunotherapy and vaccines design.
American Psychological Association (APA)
Viganò, Selena& Utzschneider, Daniel T.& Perreau, Matthieu& Pantaleo, Giuseppe& Zehn, Dietmar& Harari, Alexandre. 2012. Functional Avidity : A Measure to Predict the Efficacy of Effector T Cells?. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-450095
Modern Language Association (MLA)
Viganò, Selena…[et al.]. Functional Avidity : A Measure to Predict the Efficacy of Effector T Cells?. Clinical and Developmental Immunology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-450095
American Medical Association (AMA)
Viganò, Selena& Utzschneider, Daniel T.& Perreau, Matthieu& Pantaleo, Giuseppe& Zehn, Dietmar& Harari, Alexandre. Functional Avidity : A Measure to Predict the Efficacy of Effector T Cells?. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-450095
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450095