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Involvement of DNA Damage Response Pathways in Hepatocellular Carcinoma
Joint Authors
Chang, Chien-Wei
Yang, Sheau-Fang
Shiue, Yow-Ling
Yeh, Yao-Tsung
Wei, Ren-Jie
Wang, Shen-Nien
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-28
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) has been known as one of the most lethal human malignancies, due to the difficulty of early detection, chemoresistance, and radioresistance, and is characterized by active angiogenesis and metastasis, which account for rapid recurrence and poor survival.
Its development has been closely associated with multiple risk factors, including hepatitis B and C virus infection, alcohol consumption, obesity, and diet contamination.
Genetic alterations and genomic instability, probably resulted from unrepaired DNA lesions, are increasingly recognized as a common feature of human HCC.
Dysregulation of DNA damage repair and signaling to cell cycle checkpoints, known as the DNA damage response (DDR), is associated with a predisposition to cancer and affects responses to DNA-damaging anticancer therapy.
It has been demonstrated that various HCC-associated risk factors are able to promote DNA damages, formation of DNA adducts, and chromosomal aberrations.
Hence, alterations in the DDR pathways may accumulate these lesions to trigger hepatocarcinogenesis and also to facilitate advanced HCC progression.
This review collects some of the most known information about the link between HCC-associated risk factors and DDR pathways in HCC.
Hopefully, the review will remind the researchers and clinicians of further characterizing and validating the roles of these DDR pathways in HCC.
American Psychological Association (APA)
Yang, Sheau-Fang& Chang, Chien-Wei& Wei, Ren-Jie& Shiue, Yow-Ling& Wang, Shen-Nien& Yeh, Yao-Tsung. 2014. Involvement of DNA Damage Response Pathways in Hepatocellular Carcinoma. BioMed Research International،Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-450096
Modern Language Association (MLA)
Yang, Sheau-Fang…[et al.]. Involvement of DNA Damage Response Pathways in Hepatocellular Carcinoma. BioMed Research International No. 2014 (2014), pp.1-18.
https://search.emarefa.net/detail/BIM-450096
American Medical Association (AMA)
Yang, Sheau-Fang& Chang, Chien-Wei& Wei, Ren-Jie& Shiue, Yow-Ling& Wang, Shen-Nien& Yeh, Yao-Tsung. Involvement of DNA Damage Response Pathways in Hepatocellular Carcinoma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-450096
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450096