Essential Oils and Their Constituents as Anticancer Agents : A Mechanistic View
Joint Authors
Gautam, Nandini
Mittal, Sunil
Mantha, Anil K.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-09
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research.
Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and the present review is an attempt to collect and document the available studies indicating EOs and their constituents as anticancer agents.
This review enlists nearly 130 studies of EOs from various plant species and their constituents that have been studied so far for their anticancer potential and these studies have been classified as in vitro and in vivo studies for EOs and their constituents.
This review also highlights in-depth various mechanisms of action of different EOs and their constituents reported in the treatment strategies for different types of cancer.
The current review indicates that EOs and their constituents act by multiple pathways and mechanisms involving apoptosis, cell cycle arrest, antimetastatic and antiangiogenic, increased levels of reactive oxygen and nitrogen species (ROS/RNS), DNA repair modulation, and others to demonstrate their antiproliferative activity in the cancer cell.
The effect of EOs and their constituents on tumour suppressor proteins (p53 and Akt), transcription factors (NF-κB and AP-1), MAPK-pathway, and detoxification enzymes like SOD, catalase, glutathione peroxidase, and glutathione reductase has also been discussed.
American Psychological Association (APA)
Gautam, Nandini& Mantha, Anil K.& Mittal, Sunil. 2014. Essential Oils and Their Constituents as Anticancer Agents : A Mechanistic View. BioMed Research International،Vol. 2014, no. 2014, pp.1-23.
https://search.emarefa.net/detail/BIM-450124
Modern Language Association (MLA)
Gautam, Nandini…[et al.]. Essential Oils and Their Constituents as Anticancer Agents : A Mechanistic View. BioMed Research International No. 2014 (2014), pp.1-23.
https://search.emarefa.net/detail/BIM-450124
American Medical Association (AMA)
Gautam, Nandini& Mantha, Anil K.& Mittal, Sunil. Essential Oils and Their Constituents as Anticancer Agents : A Mechanistic View. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-23.
https://search.emarefa.net/detail/BIM-450124
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450124