(+)-Z-Bisdehydrodoisynolic Acid Enhances Basal Metabolism and Fatty Acid Oxidation in Female Obese Zucker Rats
Joint Authors
Meyers, Cal Y.
Banz, William J.
Strader, April D.
Davis, Jeremy E.
Hou, Yuqing
Ajuwon, Kolapo M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We have previously reported that the synthetic estrogen, (+)-Z-bisdehydrodoisynolic Acid [(+)-Z-BDDA], attenuated weight gain and cardiovascular risk in obese rodents.
To determine if these antiobesity effects were attributed to changes in basal metabolism, we assessed indirect calorimetry and metabolic profile in female obese Zucker (OZR) rats provided (+)-Z-BDDA (0.0002% food admixture) for 11 weeks.
Similar to our previous findings, (+)-Z-BDDA reduced weight gain and improved lipid and glucose homeostasis in OZR rats.
Furthermore, resting energy expenditure was increased by (+)-Z-BDDA, as evident by heat production and oxygen consumption.
We also observed a marked reduction in respiratory quotient (RQ) along with a corresponding induction of hepatic AMPK in rodents provided (+)-Z-BDDA.
Collectively, these findings indicate that (+)-Z-BDDA partially attenuated obesity and associated pathologies through increased resting energy expenditure and fatty acid utilization.
Further investigation is required to fully elucidate the mechanisms involved as well as to determine the potential therapeutic implications for (+)-Z-BDDA on obesity and its related pathologies.
American Psychological Association (APA)
Banz, William J.& Strader, April D.& Ajuwon, Kolapo M.& Hou, Yuqing& Meyers, Cal Y.& Davis, Jeremy E.. 2012. (+)-Z-Bisdehydrodoisynolic Acid Enhances Basal Metabolism and Fatty Acid Oxidation in Female Obese Zucker Rats. Journal of Obesity،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-450128
Modern Language Association (MLA)
Banz, William J.…[et al.]. (+)-Z-Bisdehydrodoisynolic Acid Enhances Basal Metabolism and Fatty Acid Oxidation in Female Obese Zucker Rats. Journal of Obesity No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-450128
American Medical Association (AMA)
Banz, William J.& Strader, April D.& Ajuwon, Kolapo M.& Hou, Yuqing& Meyers, Cal Y.& Davis, Jeremy E.. (+)-Z-Bisdehydrodoisynolic Acid Enhances Basal Metabolism and Fatty Acid Oxidation in Female Obese Zucker Rats. Journal of Obesity. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-450128
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450128