RASSF1A Signaling in the Heart : Novel Functions beyond Tumor Suppression
Joint Authors
Del Re, Dominic P.
Sadoshima, Junichi
Source
Molecular Biology International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The RASSF proteins are a family of polypeptides, each containing a conserved Ras association domain, suggesting that these scaffold proteins may be effectors of activated Ras or Ras-related small GTPases.
RASSF proteins are characterized by their ability to inhibit cell growth and proliferation while promoting cell death.
RASSF1 isoform A is an established tumor suppressor and is frequently silenced in a variety of tumors and human cancer cell lines.
However, our understanding of its function in terminally differentiated cell types, such as cardiac myocytes, is relatively nascent.
Herein, we review the role of RASSF1A in cardiac physiology and disease and highlight signaling pathways that mediate its function.
American Psychological Association (APA)
Del Re, Dominic P.& Sadoshima, Junichi. 2012. RASSF1A Signaling in the Heart : Novel Functions beyond Tumor Suppression. Molecular Biology International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-450142
Modern Language Association (MLA)
Del Re, Dominic P.& Sadoshima, Junichi. RASSF1A Signaling in the Heart : Novel Functions beyond Tumor Suppression. Molecular Biology International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-450142
American Medical Association (AMA)
Del Re, Dominic P.& Sadoshima, Junichi. RASSF1A Signaling in the Heart : Novel Functions beyond Tumor Suppression. Molecular Biology International. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-450142
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450142