Bioinformatics Identification of Modules of Transcription Factor Binding Sites in Alzheimer's Disease-Related Genes by In Silico Promoter Analysis and Microarrays
Joint Authors
Lichtenthaler, Stefan F.
Augustin, Regina
Hansen, Jens
Wurst, Wolfgang
Greeff, Michael
Trümbach, Dietrich
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The molecular mechanisms and genetic risk factors underlying Alzheimer's disease (AD) pathogenesis are only partly understood.
To identify new factors, which may contribute to AD, different approaches are taken including proteomics, genetics, and functional genomics.
Here, we used a bioinformatics approach and found that distinct AD-related genes share modules of transcription factor binding sites, suggesting a transcriptional coregulation.
To detect additional coregulated genes, which may potentially contribute to AD, we established a new bioinformatics workflow with known multivariate methods like support vector machines, biclustering, and predicted transcription factor binding site modules by using in silico analysis and over 400 expression arrays from human and mouse.
Two significant modules are composed of three transcription factor families: CTCF, SP1F, and EGRF/ZBPF, which are conserved between human and mouse APP promoter sequences.
The specific combination of in silico promoter and multivariate analysis can identify regulation mechanisms of genes involved in multifactorial diseases.
American Psychological Association (APA)
Augustin, Regina& Lichtenthaler, Stefan F.& Greeff, Michael& Hansen, Jens& Wurst, Wolfgang& Trümbach, Dietrich. 2011. Bioinformatics Identification of Modules of Transcription Factor Binding Sites in Alzheimer's Disease-Related Genes by In Silico Promoter Analysis and Microarrays. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-450149
Modern Language Association (MLA)
Augustin, Regina…[et al.]. Bioinformatics Identification of Modules of Transcription Factor Binding Sites in Alzheimer's Disease-Related Genes by In Silico Promoter Analysis and Microarrays. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-450149
American Medical Association (AMA)
Augustin, Regina& Lichtenthaler, Stefan F.& Greeff, Michael& Hansen, Jens& Wurst, Wolfgang& Trümbach, Dietrich. Bioinformatics Identification of Modules of Transcription Factor Binding Sites in Alzheimer's Disease-Related Genes by In Silico Promoter Analysis and Microarrays. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-450149
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450149