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Intrathecal Trastuzumab Treatment of the Neoplastic Meningitis due to Breast Cancer : A Case Report and Review of the Literature
Joint Authors
Dumitrescu, Cristina
Lossignol, Dominique
Source
Case Reports in Oncological Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We report the case of a 65-year-old woman, diagnosed with a breast cancer human epidermal growth factor receptor (HER2) previously negative, who developed leptomeningeal carcinomatosis and was treated with intrathecal (IT) trastuzumab (TST).
After five doses of IT trastuzumab, at escalading doses, once weekly, the patient's neurological status stabilised, and that result was maintained for two months.
There is evidence in the literature that breast cancer receptor status may change over time, and when it occurs, it may modify the therapeutical approach.
We reviewed the pertinent literature and concluded that IT trastuzumab might be a promising treatment for patients with HER2-positive breast cancer leptomeningeal carcinomatosis.
American Psychological Association (APA)
Dumitrescu, Cristina& Lossignol, Dominique. 2013. Intrathecal Trastuzumab Treatment of the Neoplastic Meningitis due to Breast Cancer : A Case Report and Review of the Literature. Case Reports in Oncological Medicine،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-450178
Modern Language Association (MLA)
Dumitrescu, Cristina& Lossignol, Dominique. Intrathecal Trastuzumab Treatment of the Neoplastic Meningitis due to Breast Cancer : A Case Report and Review of the Literature. Case Reports in Oncological Medicine No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-450178
American Medical Association (AMA)
Dumitrescu, Cristina& Lossignol, Dominique. Intrathecal Trastuzumab Treatment of the Neoplastic Meningitis due to Breast Cancer : A Case Report and Review of the Literature. Case Reports in Oncological Medicine. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-450178
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450178