Molecular Diagnostics, Targeted Therapy, and the Indication for Allogeneic Stem Cell Transplantation in Acute Lymphoblastic Leukemia
Joint Authors
Klyuchnikov, Evgeny
Haferlach, Torsten
Schnittger, Susanne
Kröger, Nicolaus
Bacher, Ulrike
Oyekunle, Anthony
Zander, Axel Rolf
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In recent years, the panel of known molecular mutations in acute lymphoblastic leukemia (ALL) has been continuously increased.
In Philadelphia-positive ALL, deletions of the IKZF1 gene were identified as prognostically adverse factors.
These improved insights in the molecular background and the clinical heterogeneity of distinct cytogenetic subgroups may allow most differentiated therapeutic decisions, for example, with respect to the indication to allogeneic HSCT within genetically defined ALL subtypes.
Quantitative real-time PCR allows highly sensitive monitoring of the minimal residual disease (MRD) load, either based on reciprocal gene fusions or immune gene rearrangements.
Molecular diagnostics provided the basis for targeted therapy concepts, for example, combining the tyrosine kinase inhibitor imatinib with chemotherapy in patients with Philadelphia-positive ALL.
Screening for BCR-ABL1 mutations in Philadelphia-positive ALL allows to identify patients who may benefit from second-generation tyrosine kinase inhibitors or from novel compounds targeting the T315I mutation.
Considering the central role of the molecular techniques for the management of patients with ALL, efforts should be made to facilitate and harmonize immunophenotyping, cytogenetics, and molecular mutation screening.
Furthermore, the potential of high-throughput sequencing should be evaluated for diagnosis and follow-up of patients with B-lineage ALL.
American Psychological Association (APA)
Oyekunle, Anthony& Haferlach, Torsten& Kröger, Nicolaus& Klyuchnikov, Evgeny& Zander, Axel Rolf& Schnittger, Susanne…[et al.]. 2011. Molecular Diagnostics, Targeted Therapy, and the Indication for Allogeneic Stem Cell Transplantation in Acute Lymphoblastic Leukemia. Advances in Hematology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-450188
Modern Language Association (MLA)
Oyekunle, Anthony…[et al.]. Molecular Diagnostics, Targeted Therapy, and the Indication for Allogeneic Stem Cell Transplantation in Acute Lymphoblastic Leukemia. Advances in Hematology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-450188
American Medical Association (AMA)
Oyekunle, Anthony& Haferlach, Torsten& Kröger, Nicolaus& Klyuchnikov, Evgeny& Zander, Axel Rolf& Schnittger, Susanne…[et al.]. Molecular Diagnostics, Targeted Therapy, and the Indication for Allogeneic Stem Cell Transplantation in Acute Lymphoblastic Leukemia. Advances in Hematology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-450188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450188