Antineuropathic and Antinociceptive Drugs Combination in Patients with Chronic Low Back Pain : A Systematic Review
Joint Authors
Lacerenza, Marco
Romanò, Delia
Romanò, Carlo Luca
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
Chronic low back pain (LBP) is often characterized by both nociceptive and neuropathic components.
While various monotherapies have been reported of only limited efficacy, combining drugs with different mechanisms of action and targets appears a rational approach.
Aim of this systematic review is to assess the efficacy and safety of different combined pharmacological treatments, compared to monotherapy or placebo, for the pharmacological treatment of chronic LBP.
Methods.
Published papers, written or abstracted in English from 1990 through 2011, comparing combined pharmacological treatments of chronic LBP to monotherapy or placebo were reviewed.
Results.
Six articles met the inclusion criteria.
Pregabalin combined with celecoxib or opioids was shown to be more effective than either monotherapy.
Oxycodone-paracetamol versus previous treatments and tramadol-paracetamol versus placebo were also reported as effective, while morphine-nortriptyline did not show any benefit over any single agent.
Conclusions.
In spite of theoretical advantages of combined pharmacological treatments of chronic LBP, clinical studies are remarkably few.
Available data show that combined therapy, including antinociceptive and antineuropathic agents is more effective than monotherapy, with similar side effects.
American Psychological Association (APA)
Romanò, Carlo Luca& Romanò, Delia& Lacerenza, Marco. 2012. Antineuropathic and Antinociceptive Drugs Combination in Patients with Chronic Low Back Pain : A Systematic Review. Pain Research and Treatment،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-450190
Modern Language Association (MLA)
Romanò, Carlo Luca…[et al.]. Antineuropathic and Antinociceptive Drugs Combination in Patients with Chronic Low Back Pain : A Systematic Review. Pain Research and Treatment No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-450190
American Medical Association (AMA)
Romanò, Carlo Luca& Romanò, Delia& Lacerenza, Marco. Antineuropathic and Antinociceptive Drugs Combination in Patients with Chronic Low Back Pain : A Systematic Review. Pain Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-450190
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450190