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Defects in Tendon, Ligament, and Enthesis in Response to Genetic Alterations in Key Proteoglycans and Glycoproteins : A Review
Joint Authors
Veillette, Christian
Juneja, Subhash C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-30, 30 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-10
Country of Publication
Egypt
No. of Pages
30
Main Subjects
Abstract EN
This review summarizes the genetic alterations and knockdown approaches published in the literature to assess the role of key proteoglycans and glycoproteins in the structural development, function, and repair of tendon, ligament, and enthesis.
The information was collected from (i) genetically altered mice, (ii) in vitro knockdown studies, (iii) genetic variants predisposition to injury, and (iv) human genetic diseases.
The genes reviewed are for small leucine-rich proteoglycans (lumican, fibromodulin, biglycan, decorin, and asporin); dermatan sulfate epimerase (Dse) that alters structure of glycosaminoglycan and hence the function of small leucine-rich proteoglycans by converting glucuronic to iduronic acid; matricellular proteins (thrombospondin 2, secreted phosphoprotein 1 (Spp1), secreted protein acidic and rich in cysteine (Sparc), periostin, and tenascin X) including human tenascin C variants; and others, such as tenomodulin, leukocyte cell derived chemotaxin 1 (chondromodulin-I, ChM-I), CD44 antigen (Cd44), lubricin (Prg4), and aggrecan degrading gene, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (Adamts5).
Understanding these genes represents drug targets for disrupting pathological mechanisms that lead to tendinopathy, ligamentopathy, enthesopathy, enthesitis and tendon/ligament injury, that is, osteoarthritis and ankylosing spondylitis.
American Psychological Association (APA)
Juneja, Subhash C.& Veillette, Christian. 2013. Defects in Tendon, Ligament, and Enthesis in Response to Genetic Alterations in Key Proteoglycans and Glycoproteins : A Review. Arthritis،Vol. 2013, no. 2013, pp.1-30.
https://search.emarefa.net/detail/BIM-450195
Modern Language Association (MLA)
Juneja, Subhash C.& Veillette, Christian. Defects in Tendon, Ligament, and Enthesis in Response to Genetic Alterations in Key Proteoglycans and Glycoproteins : A Review. Arthritis No. 2013 (2013), pp.1-30.
https://search.emarefa.net/detail/BIM-450195
American Medical Association (AMA)
Juneja, Subhash C.& Veillette, Christian. Defects in Tendon, Ligament, and Enthesis in Response to Genetic Alterations in Key Proteoglycans and Glycoproteins : A Review. Arthritis. 2013. Vol. 2013, no. 2013, pp.1-30.
https://search.emarefa.net/detail/BIM-450195
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450195