Mitochondrial Stress Signaling Promotes Cellular Adaptations
Joint Authors
Barbour, Jayne Alexandra
Turner, Nigel
Source
International Journal of Cell Biology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Mitochondrial dysfunction has been implicated in the aetiology of many complex diseases, as well as the ageing process.
Much of the research on mitochondrial dysfunction has focused on how mitochondrial damage may potentiate pathological phenotypes.
The purpose of this review is to draw attention to the less well-studied mechanisms by which the cell adapts to mitochondrial perturbations.
This involves communication of stress to the cell and successful induction of quality control responses, which include mitophagy, unfolded protein response, upregulation of antioxidant and DNA repair enzymes, morphological changes, and if all else fails apoptosis.
The mitochondrion is an inherently stressful environment and we speculate that dysregulation of stress signaling or an inability to switch on these adaptations during times of mitochondrial stress may underpin mitochondrial dysfunction and hence amount to pathological states over time.
American Psychological Association (APA)
Barbour, Jayne Alexandra& Turner, Nigel. 2014. Mitochondrial Stress Signaling Promotes Cellular Adaptations. International Journal of Cell Biology،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-450224
Modern Language Association (MLA)
Barbour, Jayne Alexandra& Turner, Nigel. Mitochondrial Stress Signaling Promotes Cellular Adaptations. International Journal of Cell Biology No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-450224
American Medical Association (AMA)
Barbour, Jayne Alexandra& Turner, Nigel. Mitochondrial Stress Signaling Promotes Cellular Adaptations. International Journal of Cell Biology. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-450224
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450224