Paraoxonase-1 Inhibits Oxidized Low-Density Lipoprotein-Induced Metabolic Alterations and Apoptosis in Endothelial Cells : A Nondirected Metabolomic Study
Joint Authors
Fort, Isabel
Mackness, Michael
Shih, Diana M.
Joven, Jorge
Triguero, Iris
Mackness, Bharti
Rull, Anna
Marsillach, Judit
Camps, Jordi
García-Heredia, Anabel
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We studied the influence of PON1 on metabolic alterations induced by oxidized LDL when incubated with endothelial cells.
HUVEC cells were incubated with native LDL, oxidized LDL, oxidized LDL plus HDL from wild type mice, and oxidized LDL plus HDL from PON1-deficient mice.
Results showed alterations in carbohydrate and phospholipid metabolism and increased apoptosis in cells incubated with oxidized LDL.
These changes were partially prevented by wild type mouse HDL, but the effects were less effective with HDL from PON1-deficient mice.
Our results suggest that PON1 may play a significant role in endothelial cell survival by protecting cells from alterations in the respiratory chain induced by oxidized LDL.
These results extend current knowledge on the protective role of HDL and PON1 against oxidation and apoptosis in endothelial cells.
American Psychological Association (APA)
García-Heredia, Anabel& Marsillach, Judit& Rull, Anna& Triguero, Iris& Fort, Isabel& Mackness, Bharti…[et al.]. 2013. Paraoxonase-1 Inhibits Oxidized Low-Density Lipoprotein-Induced Metabolic Alterations and Apoptosis in Endothelial Cells : A Nondirected Metabolomic Study. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-450231
Modern Language Association (MLA)
García-Heredia, Anabel…[et al.]. Paraoxonase-1 Inhibits Oxidized Low-Density Lipoprotein-Induced Metabolic Alterations and Apoptosis in Endothelial Cells : A Nondirected Metabolomic Study. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-450231
American Medical Association (AMA)
García-Heredia, Anabel& Marsillach, Judit& Rull, Anna& Triguero, Iris& Fort, Isabel& Mackness, Bharti…[et al.]. Paraoxonase-1 Inhibits Oxidized Low-Density Lipoprotein-Induced Metabolic Alterations and Apoptosis in Endothelial Cells : A Nondirected Metabolomic Study. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-450231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450231