The Brain-Heart Connection : Frontal Cortex and Left Ventricle Angiotensinase Activities in Control and Captopril-Treated Hypertensive Rats—A Bilateral Study
Joint Authors
Villarejo, Ana B.
Ramírez-Sánchez, Manuel
Segarra, Ana B.
Wangensteen, Rosemary
Vives, Francisco
Banegas, Inmaculada
Gasparo, Marc de
Prieto, Isabel
Source
International Journal of Hypertension
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The model of neurovisceral integration suggests that the frontal cortex (FC) and the cardiovascular function are reciprocally and asymmetrically connected.
We analyzed several angiotensinase activities in the heart left ventricle (VT) of control and captopril-treated SHR, and we search for a relationship between these activities and those determined in the left and right FC.
Captopril was administered in drinking water for 4 weeks.
Samples from the left VT and from the left and right FC were obtained.
Soluble and membrane-bound enzymatic activities were measured fluorometrically using arylamides as substrates.
The weight of heart significantly decreased after treatment with captopril, mainly, due to the reduction of the left VT weight.
In the VT, no differences for soluble activities were observed between control and treated SHR.
In contrast, a generalized significant reduction was observed for membrane-bound activities.
The most significant correlations between FC and VT were observed in the right FC of the captopril-treated group.
The other correlations, right FC versus VT and left FC versus VT in controls and left FC versus VT in the captopril group, were few and low.
These results confirm that the connection between FC and cardiovascular system is asymmetrically organized.
American Psychological Association (APA)
Segarra, Ana B.& Prieto, Isabel& Banegas, Inmaculada& Villarejo, Ana B.& Wangensteen, Rosemary& Gasparo, Marc de…[et al.]. 2013. The Brain-Heart Connection : Frontal Cortex and Left Ventricle Angiotensinase Activities in Control and Captopril-Treated Hypertensive Rats—A Bilateral Study. International Journal of Hypertension،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-450245
Modern Language Association (MLA)
Segarra, Ana B.…[et al.]. The Brain-Heart Connection : Frontal Cortex and Left Ventricle Angiotensinase Activities in Control and Captopril-Treated Hypertensive Rats—A Bilateral Study. International Journal of Hypertension No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-450245
American Medical Association (AMA)
Segarra, Ana B.& Prieto, Isabel& Banegas, Inmaculada& Villarejo, Ana B.& Wangensteen, Rosemary& Gasparo, Marc de…[et al.]. The Brain-Heart Connection : Frontal Cortex and Left Ventricle Angiotensinase Activities in Control and Captopril-Treated Hypertensive Rats—A Bilateral Study. International Journal of Hypertension. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-450245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450245