Experimental Validation of Methods for Prophylaxis against Deep Venous Thrombosis : A Review and Proposal
Joint Authors
Silver, Ian A.
Agutter, Paul S.
Malone, P. Colm
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The experimental procedure by which the valve cusp hypoxia (VCH) hypothesis of the etiology of deep venous thrombosis (DVT) was confirmed lends itself to testing of methods of prophylaxis.
Similar animal experiments could end the present exclusive reliance on statistical analysis of data from large patient cohorts to evaluate prophylactic regimes.
The reduction of need for such (usually retrospective) analyses could enable rationally-based clinical trials of prophylactic methods to be conducted more rapidly, and the success of such trials would lead to decreased incidences of DVT-related mortality and morbidity.
This paper reviews the VCH hypothesis (“VCH thesis”, following its corroboration) and its implications for understanding DVT and its sequelae, and outlines the experimental protocol for testing prophylactic methods.
The advantages and limitations of the protocol are briefly discussed.
American Psychological Association (APA)
Agutter, Paul S.& Malone, P. Colm& Silver, Ian A.. 2012. Experimental Validation of Methods for Prophylaxis against Deep Venous Thrombosis : A Review and Proposal. Thrombosis،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-450272
Modern Language Association (MLA)
Agutter, Paul S.…[et al.]. Experimental Validation of Methods for Prophylaxis against Deep Venous Thrombosis : A Review and Proposal. Thrombosis No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-450272
American Medical Association (AMA)
Agutter, Paul S.& Malone, P. Colm& Silver, Ian A.. Experimental Validation of Methods for Prophylaxis against Deep Venous Thrombosis : A Review and Proposal. Thrombosis. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-450272
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450272