Short-and Long-Term Clinical Outcomes of Infliximab in Fulminant Ulcerative Colitis

Joint Authors

Rismo, R.
Cui, Guanglin
Paulssen, E. J.
Goll, R.
Øverland, G.
Christiansen, I.
Florholmen, J.
Olsen, T.

Source

Ulcers

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-01-03

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases

Abstract EN

The aim was to characterize short- and long-term clinical outcomes of infliximab in fulminant ulcerative colitis.

Patients with severe ulcerative colitis meeting the criteria of fulminant colitis after 3 days of glucocorticosteroid treatment were randomized to control or additional induction therapy of infliximab followed by an on demand/maintenance therapy of infliximab.

Twenty six patients with fulminant colitis were equally randomized.

At Day 7, ten patients in the control group and none in the infliximab group were in the need of colectomy (P<.001).

Due to superior effect of infliximab, patients in the control group were of ethical reasons transformed to infliximab treatment instead of performing colectomy.

The probability to avoid colectomy was 0.66 with a median observation time of 52 months and a maximal of 91 months.

The addition of azathioprine reduced the risk of late colectomy.

We conclude that infliximab is effective in preventing early and late colectomy in fulminant colitis.

American Psychological Association (APA)

Florholmen, J.& Øverland, G.& Olsen, T.& Rismo, R.& Cui, Guanglin& Christiansen, I.…[et al.]. 2011. Short-and Long-Term Clinical Outcomes of Infliximab in Fulminant Ulcerative Colitis. Ulcers،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-450273

Modern Language Association (MLA)

Florholmen, J.…[et al.]. Short-and Long-Term Clinical Outcomes of Infliximab in Fulminant Ulcerative Colitis. Ulcers No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-450273

American Medical Association (AMA)

Florholmen, J.& Øverland, G.& Olsen, T.& Rismo, R.& Cui, Guanglin& Christiansen, I.…[et al.]. Short-and Long-Term Clinical Outcomes of Infliximab in Fulminant Ulcerative Colitis. Ulcers. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-450273

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-450273