Electroacupuncture Ameliorates Learning and Memory via Activation of the CREB Signaling Pathway in the Hippocampus to Attenuate Apoptosis after Cerebral Hypoperfusion
Joint Authors
Liu, Fang
Lu, Min
Guo, Feng
Huang, Xiaolin
Zhao, Xiuxiu
Han, Xiaohua
Zhang, Jinghui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Studies have shown that electroacupuncture (EA) ameliorates learning and memory after ischemic injury.
However, there have been few studies elucidating the mechanisms of EA on learning and memory in cerebral hypoperfusion.
In this study, we explored the cAMP response element-binding protein (CREB) signaling pathway-mediated antiapoptotic action involved in EA-induced improvement of learning and memory.
EA at GV20 and GV14 acupoints was applied in cerebral hypoperfusion rats.
A Morris water maze task was performed, and the immunoreactivities of pCREB, Bcl-2, and Bax in the hippocampal CA1 area were evaluated by the Western blotting technique.
Our findings indicated that (1) EA ameliorated spatial learning and memory impairment in cerebral hypoperfusion rats; (2) EA increased the immunoreactivities of pCREB and Bcl-2 and decreased the immunoreactivity of Bax; (3) intracerebroventricular administration of H89 (the inhibitor of protein kinase A) blocked EA-induced, pCREB-mediated antiapoptotic action and improved learning and memory.
These results suggest that EA can ameliorate learning and memory via activation of the CREB signaling pathway in the hippocampus to attenuate apoptosis after cerebral hypoperfusion.
American Psychological Association (APA)
Han, Xiaohua& Zhao, Xiuxiu& Lu, Min& Liu, Fang& Guo, Feng& Zhang, Jinghui…[et al.]. 2013. Electroacupuncture Ameliorates Learning and Memory via Activation of the CREB Signaling Pathway in the Hippocampus to Attenuate Apoptosis after Cerebral Hypoperfusion. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-450280
Modern Language Association (MLA)
Han, Xiaohua…[et al.]. Electroacupuncture Ameliorates Learning and Memory via Activation of the CREB Signaling Pathway in the Hippocampus to Attenuate Apoptosis after Cerebral Hypoperfusion. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-450280
American Medical Association (AMA)
Han, Xiaohua& Zhao, Xiuxiu& Lu, Min& Liu, Fang& Guo, Feng& Zhang, Jinghui…[et al.]. Electroacupuncture Ameliorates Learning and Memory via Activation of the CREB Signaling Pathway in the Hippocampus to Attenuate Apoptosis after Cerebral Hypoperfusion. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-450280
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450280