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Malarial Infection of Female BWF1 Lupus Mice Alters the Redox State in Kidney and Liver Tissues and Confers Protection against Lupus Nephritis
Joint Authors
El-Amir, Azza
Abdel-Maksoud, Mostafa A.
Abdel-Ghaffar, Fathy A.
Badr, Gamal
al-Quraishy, Salih
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by an imbalanced redox state and increased apoptosis.
Tropical infections, particularly malaria, may confer protection against SLE.
Oxidative stress is a hallmark of SLE.
We have measured changes in the levels of nitric oxide (NO), hydrogen peroxide (H2O2), malondialdehyde (MDA), and reduced glutathione (GSH) in both kidney and liver tissues of female BWF1 lupus mice, an experimental model of SLE, after infection with either live or gamma-irradiated malaria.
We observed a decrease in NO, H2O2, and MDA levels in kidney tissues after infection of lupus mice with live malaria.
Similarly, the levels of NO and H2O2 were significantly decreased in the liver tissues of lupus mice after infection with live malaria.
Conversely, GSH levels were obviously increased in both kidney and liver tissues after infection of lupus mice with either live or gamma-irradiated malaria.
Liver and kidney functions were significantly altered after infection of lupus mice with live malaria.
We further investigated the ultrastructural changes and detected the number of apoptotic cells in kidney and liver tissues in situ by electron microscopy and TUNEL assays.
Our data reveal that infection of lupus mice with malaria confers protection against lupus nephritis.
American Psychological Association (APA)
al-Quraishy, Salih& Abdel-Maksoud, Mostafa A.& El-Amir, Azza& Abdel-Ghaffar, Fathy A.& Badr, Gamal. 2013. Malarial Infection of Female BWF1 Lupus Mice Alters the Redox State in Kidney and Liver Tissues and Confers Protection against Lupus Nephritis. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-450287
Modern Language Association (MLA)
al-Quraishy, Salih…[et al.]. Malarial Infection of Female BWF1 Lupus Mice Alters the Redox State in Kidney and Liver Tissues and Confers Protection against Lupus Nephritis. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-450287
American Medical Association (AMA)
al-Quraishy, Salih& Abdel-Maksoud, Mostafa A.& El-Amir, Azza& Abdel-Ghaffar, Fathy A.& Badr, Gamal. Malarial Infection of Female BWF1 Lupus Mice Alters the Redox State in Kidney and Liver Tissues and Confers Protection against Lupus Nephritis. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-450287
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450287