Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease
Joint Authors
Osunkwo, Ifeyinwa
Lawal, Feyisayo
Ofori-Acquah, Solomon F.
Manlove-Simmons, Jerry
Gibbons, Gary H.
Gee, Beatrice E.
Quarshie, Alexander
Buchanan, Iris D.
Quyyumi, Arshed A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We studied the number and function of angiogenic progenitor cells and growth factors in children aged 5–18 years without acute illness, 43 with Hemoglobin SS and 68 with normal hemoglobin.
Hemoglobin SS subjects had at least twice as many mononuclear cell colonies and more circulating progenitor cell than Control subjects.
Plasma concentrations of erythropoietin, angiopoietin-2, and stromal-derived growth factor (SDF)-1α were significantly higher in children with Hemoglobin SS compared to Control subjects.
In a multivariate analysis model, SDF-1α concentration was found to be associated with both CPC number and total white blood cell count in the Hemoglobin SS group, suggesting that SDF-1α produced by ischemic tissues plays a role in mobilizing these cells in children with Hemoglobin SS.
Despite having a higher number of angiogenic progenitor cells, children with Hemoglobin SS had slower migration of cultured mononuclear cells.
American Psychological Association (APA)
Ofori-Acquah, Solomon F.& Buchanan, Iris D.& Osunkwo, Ifeyinwa& Manlove-Simmons, Jerry& Lawal, Feyisayo& Quarshie, Alexander…[et al.]. 2012. Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease. Anemia،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-450293
Modern Language Association (MLA)
Ofori-Acquah, Solomon F.…[et al.]. Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease. Anemia No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-450293
American Medical Association (AMA)
Ofori-Acquah, Solomon F.& Buchanan, Iris D.& Osunkwo, Ifeyinwa& Manlove-Simmons, Jerry& Lawal, Feyisayo& Quarshie, Alexander…[et al.]. Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease. Anemia. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-450293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450293
