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Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation
Joint Authors
Xu, Shengli
Chan, Piu
Zhou, Ming
Zuo, Xiaohong
Cai, Yanning
Zhang, Ruiping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Abundant evidence has suggested that neuroinflammation participates in the pathogenesis of Parkinson's disease (PD).
The emerging evidence has supported that microglia may play key roles in the progressive neurodegeneration in PD and might be a promising therapeutic target.
Ganoderma lucidum (GL), a traditional Chinese medicinal herb, has been shown potential neuroprotective effects in our clinical trials that make us to speculate that it might possess potent anti-inflammatory and immunomodulating properties.
To test this hypothesis, we investigated the potential neuroprotective effect of GL and possible underlying mechanism of action through protecting microglial activation using co-cultures of dopaminergic neurons and microglia.
The microglia is activated by LPS and MPP+-treated MES 23.5 cell membranes.
Meanwhile, GL extracts significantly prevent the production of microglia-derived proinflammatory and cytotoxic factors [nitric oxide, tumor necrosis factor-α (TNF-α), interlukin 1β (IL-1β)] in a dose-dependent manner and down-regulate the TNF-α and IL-1β expressions on mRNA level as well.
In conclusion, our results support that GL may be a promising agent for the treatment of PD through anti-inflammation.
American Psychological Association (APA)
Zhang, Ruiping& Xu, Shengli& Cai, Yanning& Zhou, Ming& Zuo, Xiaohong& Chan, Piu. 2011. Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-450302
Modern Language Association (MLA)
Zhang, Ruiping…[et al.]. Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-450302
American Medical Association (AMA)
Zhang, Ruiping& Xu, Shengli& Cai, Yanning& Zhou, Ming& Zuo, Xiaohong& Chan, Piu. Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-450302
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450302