Airway Smooth Muscle Dynamics and Hyperresponsiveness : In and outside the Clinic
Joint Authors
James, Alan L.
Noble, Peter B.
Mitchell, Howard W.
McFawn, Peter K.
Ansell, Thomas K.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The primary functional abnormality in asthma is airway hyperresponsiveness (AHR)—excessive airway narrowing to bronchoconstrictor stimuli.
Our understanding of the underlying mechanism(s) producing AHR is incomplete.
While structure-function relationships have been evoked to explain AHR (e.g., increased airway smooth muscle (ASM) mass in asthma) more recently there has been a focus on how the dynamic mechanical environment of the lung impacts airway responsiveness in health and disease.
The effects of breathing movements such as deep inspiration reveal innate protective mechanisms in healthy individuals that are likely mediated by dynamic ASM stretch but which may be impaired in asthmatic patients and thereby facilitate AHR.
This perspective considers the evidence for and against a role of dynamic ASM stretch in limiting the capacity of airways to narrow excessively.
We propose that lung function measured after bronchial provocation in the laboratory and changes in lung function perceived by the patient in everyday life may be quite different in their dependence on dynamic ASM stretch.
American Psychological Association (APA)
Noble, Peter B.& Ansell, Thomas K.& James, Alan L.& McFawn, Peter K.& Mitchell, Howard W.. 2012. Airway Smooth Muscle Dynamics and Hyperresponsiveness : In and outside the Clinic. Journal of Allergy،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-450339
Modern Language Association (MLA)
Noble, Peter B.…[et al.]. Airway Smooth Muscle Dynamics and Hyperresponsiveness : In and outside the Clinic. Journal of Allergy No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-450339
American Medical Association (AMA)
Noble, Peter B.& Ansell, Thomas K.& James, Alan L.& McFawn, Peter K.& Mitchell, Howard W.. Airway Smooth Muscle Dynamics and Hyperresponsiveness : In and outside the Clinic. Journal of Allergy. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-450339
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450339