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Serrated Polyposis : An Enigmatic Model of Colorectal Cancer Predisposition
Joint Authors
Parry, Susan
Rosty, Christophe
Young, Joanne P.
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Serrated polyposis has only recently been accepted as a condition which carries an increased personal and familial risk of colorectal cancer.
Described over four decades ago, it remains one of the most underrecognized and poorly understood of all the intestinal polyposes.
With a variety of phenotypic presentations, it is likely that serrated polyposis represents a group of diseases rather than a single entity.
Further, neoplastic progression in serrated polyposis may be associated with premature aging in the normal mucosa, typified by widespread gene promoter hypermethylation.
From this epigenetically altered field, arise diverse polyps and cancers which show a range of molecular features.
Despite a high serrated polyp count, only one-third of colorectal cancers demonstrate a BRAF V600E mutation, the molecular hallmark of the canonical serrated pathway, suggesting that though multiple serrated polyps act as a marker of an abnormal mucosa, the majority of CRC in these patients arise within lesions other than BRAF-mutated serrated polyps.
American Psychological Association (APA)
Rosty, Christophe& Parry, Susan& Young, Joanne P.. 2011. Serrated Polyposis : An Enigmatic Model of Colorectal Cancer Predisposition. Pathology Research International،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-450344
Modern Language Association (MLA)
Rosty, Christophe…[et al.]. Serrated Polyposis : An Enigmatic Model of Colorectal Cancer Predisposition. Pathology Research International No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-450344
American Medical Association (AMA)
Rosty, Christophe& Parry, Susan& Young, Joanne P.. Serrated Polyposis : An Enigmatic Model of Colorectal Cancer Predisposition. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-450344
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450344