HMGB1 : A Promising Therapeutic Target for Prostate Cancer
Joint Authors
Munirathinam, Gnanasekar
Kajdacsy-Balla, André
Kalyanasundaram, Ramaswamy
Zheng, Guoxing
Bosland, Maarten C.
Chen, Aoshuang
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
High mobility group box 1 (HMGB1) was originally discovered as a chromatin-binding protein several decades ago.
It is now increasingly evident that HMGB1 plays a major role in several disease conditions such as atherosclerosis, diabetes, arthritis, sepsis, and cancer.
It is intriguing how deregulation of HMGB1 can result in a myriad of disease conditions.
Interestingly, HMGB1 is involved in cell proliferation, angiogenesis, and metastasis during cancer progression.
Furthermore, HMGB1 has been demonstrated to exert intracellular and extracellular functions, activating key oncogenic signaling pathways.
This paper focuses on the role of HMGB1 in prostate cancer development and highlights the potential of HMGB1 to serve as a key target for prostate cancer treatment.
American Psychological Association (APA)
Munirathinam, Gnanasekar& Kalyanasundaram, Ramaswamy& Zheng, Guoxing& Chen, Aoshuang& Bosland, Maarten C.& Kajdacsy-Balla, André. 2013. HMGB1 : A Promising Therapeutic Target for Prostate Cancer. Prostate Cancer،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-450350
Modern Language Association (MLA)
Munirathinam, Gnanasekar…[et al.]. HMGB1 : A Promising Therapeutic Target for Prostate Cancer. Prostate Cancer No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-450350
American Medical Association (AMA)
Munirathinam, Gnanasekar& Kalyanasundaram, Ramaswamy& Zheng, Guoxing& Chen, Aoshuang& Bosland, Maarten C.& Kajdacsy-Balla, André. HMGB1 : A Promising Therapeutic Target for Prostate Cancer. Prostate Cancer. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-450350
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450350