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Classifying Multigraph Models of Secondary RNA Structure Using Graph-Theoretic Descriptors
Joint Authors
Ross, Chelsea
Rockney, Alissa
Knisley, Jeff R.
Knisley, Debra J.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The prediction of secondary RNA folds from primary sequences continues to be an important area of research given the significance of RNA molecules in biological processes such as gene regulation.
To facilitate this effort, graph models of secondary structure have been developed to quantify and thereby characterize the topological properties of the secondary folds.
In this work we utilize a multigraph representation of a secondary RNA structure to examine the ability of the existing graph-theoretic descriptors to classify all possible topologies as either RNA-like or not RNA-like.
We use more than one hundred descriptors and several different machine learning approaches, including nearest neighbor algorithms, one-class classifiers, and several clustering techniques.
We predict that many more topologies will be identified as those representing RNA secondary structures than currently predicted in the RAG (RNA-As-Graphs) database.
The results also suggest which descriptors and which algorithms are more informative in classifying and exploring secondary RNA structures.
American Psychological Association (APA)
Knisley, Debra J.& Knisley, Jeff R.& Ross, Chelsea& Rockney, Alissa. 2012. Classifying Multigraph Models of Secondary RNA Structure Using Graph-Theoretic Descriptors. ISRN Bioinformatics،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-450352
Modern Language Association (MLA)
Knisley, Debra J.…[et al.]. Classifying Multigraph Models of Secondary RNA Structure Using Graph-Theoretic Descriptors. ISRN Bioinformatics No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-450352
American Medical Association (AMA)
Knisley, Debra J.& Knisley, Jeff R.& Ross, Chelsea& Rockney, Alissa. Classifying Multigraph Models of Secondary RNA Structure Using Graph-Theoretic Descriptors. ISRN Bioinformatics. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-450352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450352