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Metastatic Basal Cell Carcinoma : A Biological Continuum of Basal Cell Carcinoma?
Joint Authors
Sharma, Vikas
Negi, Muninder
Mahajan, Vikram K.
Mehta, Karaninder S.
Prabha, Neel
Abhinav, C.
Chauhan, Pushpinder S.
Sharma, Saurabh
Sharma, Anju Lath
Khatri, Gayatri
Source
Case Reports in Dermatological Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-06
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Basal cell carcinoma (BCC) accounts for 80% of all nonmelanoma skin cancers.
Its metastasis is extremely rare, ranging between 0.0028 and 0.55 of all BCC cases.
The usual metastasis to lymph nodes, lungs, bones, or skin is from the primary tumor situated in the head and neck region in nearly 85% cases.
A 69-year-old male developed progressively increasing multiple, fleshy, indurated, and at places pigmented noduloulcerative plaques over back, chest, and left axillary area 4 years after wide surgical excision of a pathologically diagnosed basal cell carcinoma.
The recurrence was diagnosed as infiltrative BCC and found metastasizing to skin, soft tissue and muscles, and pretracheal and axillary lymph nodes.
Three cycles of chemotherapy comprising intravenous cisplatin (50 mg) and 5-florouracil (5-FU, 750 mg) on 2 consecutive days and repeated at every 21 days were effective.
As it remains unclear whether metastatic BCC is itself a separate subset of basal cell carcinoma, we feel that early BCC localized at any site perhaps constitutes a biological continuum that may ultimately manifest with metastasis in some individuals and should be evaluated as such.
Long-standing BCC is itself potentially at risk of recurrence/dissemination; it is imperative to diagnose and appropriately treat all BCC lesions at the earliest.
American Psychological Association (APA)
Mehta, Karaninder S.& Mahajan, Vikram K.& Chauhan, Pushpinder S.& Sharma, Anju Lath& Sharma, Vikas& Abhinav, C.…[et al.]. 2012. Metastatic Basal Cell Carcinoma : A Biological Continuum of Basal Cell Carcinoma?. Case Reports in Dermatological Medicine،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-450358
Modern Language Association (MLA)
Mehta, Karaninder S.…[et al.]. Metastatic Basal Cell Carcinoma : A Biological Continuum of Basal Cell Carcinoma?. Case Reports in Dermatological Medicine No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-450358
American Medical Association (AMA)
Mehta, Karaninder S.& Mahajan, Vikram K.& Chauhan, Pushpinder S.& Sharma, Anju Lath& Sharma, Vikas& Abhinav, C.…[et al.]. Metastatic Basal Cell Carcinoma : A Biological Continuum of Basal Cell Carcinoma?. Case Reports in Dermatological Medicine. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-450358
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450358