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Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA Repair
Joint Authors
Halliday, Gary M.
Damian, Diona L.
Surjana, Devita
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Nicotinamide is a water-soluble amide form of niacin (nicotinic acid or vitamin B3).
Both niacin and nicotinamide are widely available in plant and animal foods, and niacin can also be endogenously synthesized in the liver from dietary tryptophan.
Nicotinamide is also commercially available in vitamin supplements and in a range of cosmetic, hair, and skin preparations.
Nicotinamide is the primary precursor of nicotinamide adenine dinucleotide (NAD+), an essential coenzyme in ATP production and the sole substrate of the nuclear enzyme poly-ADP-ribose polymerase-1 (PARP-1).
Numerous in vitro and in vivo studies have clearly shown that PARP-1 and NAD+ status influence cellular responses to genotoxicity which can lead to mutagenesis and cancer formation.
This paper will examine the role of nicotinamide in the protection from carcinogenesis, DNA repair, and maintenance of genomic stability.
American Psychological Association (APA)
Surjana, Devita& Halliday, Gary M.& Damian, Diona L.. 2010. Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA Repair. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-450397
Modern Language Association (MLA)
Surjana, Devita…[et al.]. Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA Repair. Journal of Nucleic Acids No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-450397
American Medical Association (AMA)
Surjana, Devita& Halliday, Gary M.& Damian, Diona L.. Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA Repair. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-450397
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450397