Antioxidant and Astroprotective Effects of a Pulicaria incisa Infusion
Joint Authors
Mordechay, Sharon
Telerman, Alona
Elmann, Anat
Ofir, Rivka
Erlank, Hilla
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Oxidative stress is involved in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's diseases.
Astrocytes, the most abundant glial cells in the brain, protect neurons from reactive oxygen species (ROS) and provide them with trophic support, such as glial-derived neurotrophic factor (GDNF).
Thus, any damage to astrocytes will affect neuronal survival.
In the present study, an infusion prepared from the desert plant Pulicaria incisa (Pi) was tested for its protective and antioxidant effects on astrocytes subjected to oxidative stress.
The Pi infusion attenuated the intracellular accumulation of ROS following treatment with hydrogen peroxide and zinc and prevented the H2O2-induced death of astrocytes.
The Pi infusion also exhibited an antioxidant effect in vitro and induced GDNF transcription in astrocytes.
It is proposed that this Pi infusion be further evaluated for use as a functional beverage for the prevention and/or treatment of brain injuries and neurodegenerative diseases in which oxidative stress plays a role.
American Psychological Association (APA)
Elmann, Anat& Telerman, Alona& Mordechay, Sharon& Erlank, Hilla& Ofir, Rivka. 2012. Antioxidant and Astroprotective Effects of a Pulicaria incisa Infusion. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-450399
Modern Language Association (MLA)
Elmann, Anat…[et al.]. Antioxidant and Astroprotective Effects of a Pulicaria incisa Infusion. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-450399
American Medical Association (AMA)
Elmann, Anat& Telerman, Alona& Mordechay, Sharon& Erlank, Hilla& Ofir, Rivka. Antioxidant and Astroprotective Effects of a Pulicaria incisa Infusion. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-450399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450399