Liposomal Encapsulated Rhodomyrtone : A Novel Antiacne Drug
Joint Authors
Amnuaikit, Thanaporn
Voravuthikunchai, Supayang Piyawan
Chorachoo, Julalak
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Rhodomyrtone isolated from the leaves of Rhodomyrtus tomentosa possesses antibacterial, anti-inflammatory, and anti-oxidant activities.
Since rhodomyrtone is insoluble in water, it is rather difficult to get to the target sites in human body.
Liposome exhibited ability to entrap both hydrophilic and hydrophobic compounds and easily penetrate to the target site.
The present study aimed to develop a novel liposomal encapsulated rhodomyrtone formulations.
In addition, characterization of liposome, stability profiles, and their antiacne activity were performed.
Three different formulations of total lipid concentrations 60, 80, and 100 μmol/mL were used.
Formulation with 60 μmol/mL total lipid (phosphatidylcholine from soybean and cholesterol from lanolin in 4 : 1, w/w) exhibited the highest rhodomyrtone encapsulation efficacy (65.47 ± 1.7%), average particle size (209.56 ± 4.8 nm), and ζ-potential (–41.19 ± 1.3 mV).
All formulations demonstrated good stability when stored for 2 months in dark at 4°C as well as room temperature.
Minimal inhibitory concentration and minimal bactericidal concentration values of liposomal formulation against 11 clinical bacterial isolates and reference strains ranged from 1 to 4 and from 4 to 64 μg/mL, respectively, while those of rhodomyrtone were 0.25–1 and 0.5–2 μg/mL, respectively.
The MIC and MBC values of liposome formulation were more effective than topical drugs against Staphylococcus aureus and Staphylococcus epidermidis.
American Psychological Association (APA)
Chorachoo, Julalak& Amnuaikit, Thanaporn& Voravuthikunchai, Supayang Piyawan. 2013. Liposomal Encapsulated Rhodomyrtone : A Novel Antiacne Drug. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-450403
Modern Language Association (MLA)
Chorachoo, Julalak…[et al.]. Liposomal Encapsulated Rhodomyrtone : A Novel Antiacne Drug. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-450403
American Medical Association (AMA)
Chorachoo, Julalak& Amnuaikit, Thanaporn& Voravuthikunchai, Supayang Piyawan. Liposomal Encapsulated Rhodomyrtone : A Novel Antiacne Drug. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-450403
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450403