Evaluation of Inhibitory Effect of Recreational Drugs on Dopaminergic Terminal Neuron by PET and Whole-Body Autoradiography
Joint Authors
Lin, Ming-Hsien
Hwang, Li-Chung
Yeh, Skye Hsin-Hsien
Lin, Chien-Feng
Hwang, Jeng-Jong
Kong, Fan-Lin
Liu, Ren-Shyan
Chang, Chi-Wei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
There is little investigation for the functional roles of peripheral dopamine.
[18F]FDOPA has been used in cancer imaging (i.e., neuroendocrine and tumors pancreatic tumors) and neuroimaging (i.e., Parkinson’s disease and Huntington’s disease).
Here, we accessed side effects of recreational drugs such as ketamine, cocaine, and methamphetamine on dopamine neurons in peripheral organs by using positron emission tomography (PET) imaging and quantitative whole-body autoradiography (QWBAR) with [18F]FDOPA.
The images were applied for the measurement of specific binding ratios (SBRs) of striatum with the cerebellum as the reference region.
Clear striatal [18F]FDOPA-derived radioactivity was observed.
Moderate level of radiotracer accumulation was presented in the mucosal layers of the stomach and small intestine.
The medulla layers of kidney had higher radioactivity than that of the cortex.
Blocking images markedly eliminated the specific binding of [18F]FDOPA in the striatum and in peripheral organs such as stomachs, intestines, and kidney.
Ketamine showed the highest inhibitory effect on striatal [18F]FDOPA-derived radioactivity followed by cocaine and methamphetamine.
The current results demonstrated a useful crossing-validating tool that enhances the capability of [18F]FDOPA for further investigations of the alteration of dopaminergic neurons in the brain disorder or cancer diseases in peripheral tissues.
American Psychological Association (APA)
Yeh, Skye Hsin-Hsien& Lin, Ming-Hsien& Kong, Fan-Lin& Chang, Chi-Wei& Hwang, Li-Chung& Lin, Chien-Feng…[et al.]. 2014. Evaluation of Inhibitory Effect of Recreational Drugs on Dopaminergic Terminal Neuron by PET and Whole-Body Autoradiography. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-450420
Modern Language Association (MLA)
Yeh, Skye Hsin-Hsien…[et al.]. Evaluation of Inhibitory Effect of Recreational Drugs on Dopaminergic Terminal Neuron by PET and Whole-Body Autoradiography. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-450420
American Medical Association (AMA)
Yeh, Skye Hsin-Hsien& Lin, Ming-Hsien& Kong, Fan-Lin& Chang, Chi-Wei& Hwang, Li-Chung& Lin, Chien-Feng…[et al.]. Evaluation of Inhibitory Effect of Recreational Drugs on Dopaminergic Terminal Neuron by PET and Whole-Body Autoradiography. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-450420
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450420