The Early Activation of CD8+ T Cells Is Dependent on Type I IFN Signaling following Intramuscular Vaccination of Adenovirus Vector
Joint Authors
Sakurai, Fuminori
Tsuzuki, Sayaka
Kawabata, Kenji
Kobiyama, Kouji
Akira, Shizuo
Shoji, Masaki
Hemmi, Masahisa
Ishii, Ken J.
Tachibana, Masashi
Mizuguchi, Hiroyuki
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Few of the vaccines in current use can induce antigen- (Ag-) specific immunity in both mucosal and systemic compartments.
Hence, the development of vaccines that realize both mucosal and systemic protection against various pathogens is a high priority in global health.
Recently, it has been reported that intramuscular (i.m.) vaccination of an adenovirus vector (Adv) can induce Ag-specific cytotoxic T lymphocytes (CTLs) in both systemic and gut mucosal compartments.
We previously revealed that type I IFN signaling is required for the induction of gut mucosal CTLs, not systemic CTLs.
However, the molecular mechanism via type I IFN signaling is largely unknown.
Here, we report that type I IFN signaling following i.m.
Adv vaccination is required for the expression of type I IFN in the inguinal lymph nodes (iLNs), which are the draining lymph nodes of the administration site.
We also showed that the type I IFN signaling is indispensable for the early activation of CTLs in iLNs.
These data suggested that type I IFN signaling has an important role in the translation of systemic innate immune response into mucosal adaptive immunity by amplifying the innate immune signaling and activating CTLs in the iLN.
American Psychological Association (APA)
Hemmi, Masahisa& Tachibana, Masashi& Tsuzuki, Sayaka& Shoji, Masaki& Sakurai, Fuminori& Kawabata, Kenji…[et al.]. 2014. The Early Activation of CD8+ T Cells Is Dependent on Type I IFN Signaling following Intramuscular Vaccination of Adenovirus Vector. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-450448
Modern Language Association (MLA)
Hemmi, Masahisa…[et al.]. The Early Activation of CD8+ T Cells Is Dependent on Type I IFN Signaling following Intramuscular Vaccination of Adenovirus Vector. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-450448
American Medical Association (AMA)
Hemmi, Masahisa& Tachibana, Masashi& Tsuzuki, Sayaka& Shoji, Masaki& Sakurai, Fuminori& Kawabata, Kenji…[et al.]. The Early Activation of CD8+ T Cells Is Dependent on Type I IFN Signaling following Intramuscular Vaccination of Adenovirus Vector. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-450448
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450448